Quasispecies: Concept and Implications for Virology
Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implicati
- PDF / 5,350,320 Bytes
- 412 Pages / 439.378 x 666.139 pts Page_size
- 6 Downloads / 167 Views
Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California · H. Wagner, Munich
E. Domingo (Ed.)
Quasispecies: Concept and Implications for Virology
With 44 Figures and 7 Tables
123
Esteban Domingo Centro de Biología Molecular “Servero Ochoa” (CSIC-UAM) Universidad Autónoma de Madrid Cantoblanco 28049 Madrid Spain e-mail: [email protected]
Cover illustration: Amino acid residues in the parvovirus MVMi capsid selected during evolutionary processes in mice. Highlighted in colours are residues of the spike whose replacement conferred the MAR phenotype (red), residues involved in primary receptor recognition (green), and residues conferring hematotropism (yellow). All other capsid residues are colored blue and shown as wireframe, except for the white-space-filling model of the residues defining the spike at the three-fold axis of symmetry.The structure of MVMi viral capsid is shown by the program RasMol (Sayle and Milner-White 1995) and the MVMi coordinates (1MVM) deposited in the PDB (Agbandje-McKenna et al. 1998).
Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN-10 3-540-26395-0 Springer Berlin Heidelberg New York ISBN-13 978-3-540-26395-1 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Simon Rallison, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Nadja Kroke, Leipzig Cover design: design & production GmbH, Heidelberg Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper SPIN 11501312 27/3150/YL – 5 4 3 2 1 0
Dedication
Many observations on the great potential for phenotypic change of RNA viruses were made during the twentieth century, and J
Data Loading...
