Relationships between the vascular structure and neural function of the macula in patients with diabetes mellitus
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CLINICAL INVESTIGATION
Relationships between the vascular structure and neural function of the macula in patients with diabetes mellitus Satoshi Ebihara1 · Shigeki Machida1 · Yuji Hara1 · Atsushi Tada1 · Masahiko Ishizuka1 · Mana Gonmori1 · Tomoharu Nishimura1 Received: 19 May 2020 / Accepted: 23 August 2020 © Japanese Ophthalmological Society 2020
Abstract Purpose To determine the significance of the correlation between the vascular structure and neural function of the macula in patients with diabetes mellitus. Study design Single-center observational study. Patients and methods Ninety eyes of 90 diabetic patients with an average (SD) age of 63.5 (3.8) years were studied. Fifty of the eyes had no clinically apparent diabetic retinopathy (non-DR), and 40 eyes had mild-to-moderate nonproliferative DR (NPDR). Thirty age-matched healthy individuals were also studied in the same way. Swept-source optical coherence tomography angiography (OCTA) was performed to obtain 3 × 3-mm en face images of the posterior pole of the eye. The vascular densities (VDs) of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) were determined. The focal macular electroretinograms (ERGs) elicited by a 15° circular stimulus centered on the fovea were recorded. The amplitudes of the a- and b-waves, sum of the oscillatory potentials (ΣOPs), photopic negative response (PhNR), and implicit times of the individual OPs (OP1-OP3) were measured. Results The VDs of the SCP and DCP were reduced in eyes with advanced DR (P
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