Rituximab
- PDF / 170,058 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 81 Downloads / 191 Views
1 S
Rituximab Proggressive multifocal leukoencephalopathy secondary to JC polyoma virus infection: case report
A 75-year old woman developed proggressive multifocal leukoencephalopathy secondary to JC polyoma virus infection during treatment with rituximab for follicular lymphoma. The woman, who had a medical history of follicular lymphoma and breast cancer, presented with 1 month history of confusion and difficulty with word finding, and 3 month history of gradual vision loss. Eight years prior to current presentation, she was diagnosed with hormone receptor-positive right breast cancer. For breast cancer she had undergone lumpectomy and had received treatment with an unspecified aromatase inhibitor. She had been in remission since. However, 5 years later, she was diagnosed with follicular lymphoma. At that time, she was initially treated with bendamustine and rituximab [route and dosage not stated], followed by maintenance therapy with rituximab alone for 2 years. A brain MRI at current presentation showed T2 fluid-attenuated inversion recovery hyperintensity in the left occipital and temporal lobes, crossing the corpus callosum and extending into the right occipital lobe without enhancement. She was diagnosed with progressive multifocal leukoencephalopathy. A CSF examination showed the presence of JC polyoma virus, where JC virus quantitative polymerase chain reaction showed greater than 6 million copies/mL. She was considered to have proggressive multifocal leukoencephalopathy secondary to JC polyoma virus infection, which was attributed to rituximab [duration of treatment to reaction onset not stated]. Therefore, the woman started receiving pembrolizumab. During hospitalisation, she developed septic shock, suspected to be due to Clostridium difficile colitis, and died [outcome of ADR not stated]. Yazdani M, et al. Brain Lesion in the Setting of Chronic Rituximab Treatment. JAMA Oncology 6: 1093-1094, No. 7, Jul 2020. Available from: URL: http://doi.org/10.1001/ jamaoncol.2020.0160 803504171
0114-9954/20/1824-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 3 Oct 2020 No. 1824
Data Loading...
