Sequential analysis of heart rate variability, blood pressure variability and baroreflex sensitivity in healthy pregnanc
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RESEARCH ARTICLE
Sequential analysis of heart rate variability, blood pressure variability and baroreflex sensitivity in healthy pregnancy Priyanka Garg1 · Kavita Yadav2 · Ashok Kumar Jaryal2 · Garima Kachhawa3 · Alka Kriplani3 · Kishore Kumar Deepak2 Received: 6 November 2019 / Accepted: 14 January 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objective The aim of this study was to demonstrate the temporal profile of changes in heart rate variability (HRV), blood pressure variability (BPV), and cardiac baroreflex sensitivity (BRS) during the course of a healthy pregnancy. Materials and methods This was a longitudinal study during which autonomic variability parameters (HRV, BPV, BRS) were assessed in 66 pregnant women at 11–13, 20–22 and 30–32 weeks of gestation. A lead II electrocardiogram tracing and beat-to-beat blood pressure were recorded with the subject breathing spontaneously in the supine position. Changes in the parameters were analyzed using repeated measures analysis of variance. Results Overall HRV (SDNN; standard deviation of all NN intervals) was found to decrease significantly over the course of pregnancy (p
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