Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants

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RESEARCH

Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants Todd M. Everson1*  , T. Michael O’Shea2, Amber Burt1, Karen Hermetz1, Brian S. Carter3, Jennifer Helderman4, Julie A. Hofheimer2, Elisabeth C. McGowan5, Charles R. Neal6, Steven L. Pastyrnak7, Lynne M. Smith8, Antoine Soliman9, Sheri A. DellaGrotta10, Lynne M. Dansereau10, James F. Padbury5, Barry M. Lester5,10,11 and Carmen J. Marsit1

Abstract  Background:  Infants born very preterm are more likely to experience neonatal morbidities compared to their term peers. Variations in DNA methylation (DNAm) associated with these morbidities may yield novel information about the processes impacted by these morbidities. Methods:  This study included 532 infants born