Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly:
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ORIGINAL ARTICLE
Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly: findings from the Memory and Morbidity in Augsburg Elderly (MEMO) Study Marius Zeeb & Tobias Kerrinnes & Luka Cicin-Sain & Carlos A. Guzman & Wolfram Puppe & Thomas F. Schulz & Annette Peters & Klaus Berger & Stefanie Castell & André Karch
Received: 17 April 2020 / Accepted: 11 June 2020 # The Author(s) 2020
Abstract Immunostimulation by chronic infection has been linked to an increased risk for different noncommunicable diseases, which in turn are leading causes of death in high- and middle-income countries. Thus, we investigated if a positive serostatus for pathogens responsible for common chronic infections is
individually or synergistically related to reduced overall survival in community dwelling elderly. We used data of 365 individuals from the German MEMO (Memory and Morbidity in Augsburg Elderly) cohort study with a median age of 73 years at baseline and a median followup of 14 years. We examined the effect of a positive
Stefanie Castell and André Karch. These authors contributed equally as last authors. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11357-020-00216-x) contains supplementary material, which is available to authorized users. M. Zeeb : A. Peters Institute for Medical Information Science, Biometry and Epidemiology, Ludwig Maximilians University, Munich, Germany
L. Cicin-Sain Centre for Individualised Infection Medicine (CIIM), a joint venture of HZI and MHH, Hannover, Germany
M. Zeeb Pettenkofer School of Public Health, Munich, Germany
L. Cicin-Sain : W. Puppe : T. F. Schulz German Centre for Infection Research (DZIF), Hannover-Braunschweig site, Braunschweig, Germany
M. Zeeb : T. Kerrinnes : S. Castell Department for Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Germany
W. Puppe : T. F. Schulz Institute for Virology, Hannover Medical School (MHH), Hannover, Germany
L. Cicin-Sain : C. A. Guzman Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
A. Peters German Research Center for Environmental Health, Munich, Germany
: W. Puppe : T. F. Schulz
L. Cicin-Sain Cluster of Excellence RESIST (EXC 2155), Hannover Medical School (MHH), Hannover, Germany
K. Berger : A. Karch (*) Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany e-mail: [email protected]
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serostatus at baseline for selected pathogens associated with chronic infections (Helicobacter pylori, Borrelia burgdorferi sensu lato, Toxoplasma gondii, cytomegalovirus, Epstein-Barr virus, herpes simplex virus 1/2, and human herpesvirus 6) on all-cause mortality with multivariable parametric survival models. We found a reduced survival time in individuals with a positive serostatus for Helicobacter pylori (accelerated failure time (AFT) − 15.92, 95% CI − 29.96; − 1.88), cytomegalovirus (AFT − 22.81, 95% CI − 36.
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