Serum High-Density Lipoprotein Cholesterol is Significantly Associated with the Presence and Severity of Pulmonary Arter
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ORIGINAL RESEARCH
Serum High-Density Lipoprotein Cholesterol is Significantly Associated with the Presence and Severity of Pulmonary Arterial Hypertension: A Retrospective Cross-Sectional Study Gao-Feng Wang . Li-Hua Guan . Da-Xin Zhou . Dan-Dan Chen . Xiao-Chun Zhang . Jun-BO Ge
Received: November 11, 2019 Ó Springer Healthcare Ltd., part of Springer Nature 2020
ABSTRACT Introduction: To explore the relationship between serum high-density lipoprotein cholesterol (HDL-C) levels and the presence and severity of pulmonary arterial hypertension (PAH). Methods: A total of 177 patients with PAH and 103 patients without pulmonary hypertension (PH) were enrolled in this study. All patients underwent right heart catheterization (RHC) for diagnosing and assessing the severity of PAH. Demographics, comorbidities, and laboratory data including serum HDL-C levels were collected. Results: Plasma HDL-C levels in patients with PAH were significantly lower compared with patients without PH (1.08 ± 0.36 vs 1.49 ± 0.36, p \ 0.001). HDL-C levels positively correlated with cardiac output (r = 0.360,
Enhanced digital features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.11347460. G.-F. Wang L.-H. Guan D.-X. Zhou (&) D.-D. Chen X.-C. Zhang J.-B. Ge Department of Cardiology, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China e-mail: [email protected]
p \ 0.001), cardiac index (r = 0.337, p \ 0.001), and mixed venous oxygen saturation (r = 0.426, p \ 0.001), and negatively with mean pulmonary arterial pressure (r = - 0.529, p \ 0.001), right atrial pressure (r = - 0.421, p \ 0.001), and pulmonary vascular resistance (r = - 0.583, p \ 0.001). Multivariate logistic regression analysis indicated that HDL-C was a significant independent predictor of PAH (OR 0.042, 95% CI 0.006–0.304, p = 0.002). The receiver operating characteristic curve analysis showed that the optimal cutoff value of the serum HDL-C concentration for predicting PAH was 1.32 mmol/L, with a sensitivity of 83.6% and a specificity of 72.8% (area under the curve 0.803, 95% confidence interval 0.750–0.856, p \ 0.001). Conclusions: Serum HDL-C is a simple biomarker that might be used for prediction and assessment of PAH in Chinese Han ethnicity, and the mechanism underlying the association needs further study. Keywords: Biomarker; Chinese; HDL-C; Pulmonary hypertension; Right heart catheterization
Adv Ther
Key Summary Points Pulmonary arterial hypertension (PAH) is a devastating, progressive disease. Without effective treatment, it would rapidly lead to right heart failure and premature death. As a result of the lack of specific symptoms, it is difficult for clinicians to identify PAH among suspected patients. We conducted this study to find the biomarkers of PAH and found that serum HDL-C levels were significant lower in patients with PAH compared with patients without pulmonary hypertension (1.08 ± 0.36 vs 1.49 ± 0.36, p \ 0.001). HDL-C was a significant indepen
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