Soft tissue perineurioma of the tongue: report of a case and review of the literature
- PDF / 2,669,454 Bytes
- 4 Pages / 595.276 x 793.701 pts Page_size
- 39 Downloads / 192 Views
CASE REPORT
WORLD JOURNAL OF SURGICAL ONCOLOGY
Open Access
Soft tissue perineurioma of the tongue: report of a case and review of the literature Wen-lin Xiao1*, Ling-fa Xue2 and Yao-xiang Xu1
Abstract Perineurioma is a rare benign tumor of the peripheral nervous system distinct from schwannomas and neurofibromas. It may be intraneural or extraneural (in the soft tissue). Extraneural soft tissue perineuriomas are uncommon; rare cases have been reported in the oral cavity. We present a case of soft tissue perineurioma in the tip of the tongue. The tumor was characterized by slender spindle cells, arranged in short fascicles or whorls, and focal areas showing a distinct storiform pattern. Tumor cells showed the immunohistochemical profile of perineurial cells, including epithelial membrane antigen. Smooth muscle actin, S-100, and CD34 were not expressed by the tumor cells. The tumor was surgically excised and in 2 years there has been no recurrence. Knowledge of the tumor in the oral cavity is important to reach a correct diagnosis and to avoid unnecessary aggressive local excision. Keywords: Perineurioma, Soft tissue, Tongue
Background Perineuriomas are uncommon benign nerve sheath tumors composed exclusively of well-differentiated perineurial cells [1]. They are a group of clinically and histologically heterogenous tumors that have been divided into two main types: intraneural and extraneural. The extraneural soft tissue perineurioma is generally small and clinically manifests as a painless nodule; it occurs mostly in superficial soft tissue, and infrequently affects deep soft tissue [2-4]. Recent studies have established the histological appearance and clinical behavior of the soft tissue perineurioma. It is usually a well-circumscribed, firm mass with or without spontaneous pain or tenderness. Up to now, only four cases of perineuriomas located in the tongue have been described [1,5-7], all in young people. Among them, two cases were soft tissue perineuriomas and two cases were intraneural perineuriomas. We report the first case of soft tissue perineurioma occurring in the tip of the tongue of a 46-year-old woman and describe a tongue tumor with features of soft tissue perineurioma.
* Correspondence: [email protected] 1 Department of Oral and Maxillofacial Surgery, The Medical School Hospital of Qingdao University, No. 1677, Wutaishan Road, Qingdao 266555, People’s Republic of China Full list of author information is available at the end of the article
Case presentation A 46-year-old woman presented with a slow-growing, painless intraoral swelling of 3 years duration, which was located in the tip of her tongue. The patient was previously healthy and denied genetic or familial diseases. Physical examination revealed a well-delineated, elastic, hard, nontender mass without pain. A spiral computed tomography (CT) study showed a round very well-delineated soft tissue mass centered in the muscle of the tip of the tongue with homogeneous hypodensity compared with that of muscle (Figure 1). Surgical excision
Data Loading...
