Spectroscopic Studies of CDPy Molecule in Different Protic and Aprotic Solvents and Investigation of Antioxidant Propert
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ORIGINAL ARTICLE
Spectroscopic Studies of CDPy Molecule in Different Protic and Aprotic Solvents and Investigation of Antioxidant Property Ranjana Singh 1 & Manish K. Tiwari 2 & Jyoti Goutam 3 & Ranjan K. Singh 1 Received: 20 December 2019 / Accepted: 27 July 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The properties of 3-Cyano-4, 6-Dimethyl-2-Pyridone (CDPy) were analyzed to study the antioxidant behavior. The UV-Visible absorption and fluorescence properties of CDPy have been studied in two protic (water and methanol) and two aprotic (acetonitrile and dimethyl sulfoxide) solvents. Its antioxidant properties were compared with well known antioxidant ascorbic acid. This compound, CDPy was found to exhibits moderate antioxidant properties. The experimental results were reproduced by theoretical density functional methods, which helped to understand the experimental result better. Keywords Spectroscopic studies . 3-Cyano-4,6-dimethyl-2-pyridone . Antioxidant properties
Introduction The 2-pyridone skeletons occurring in natural as well as synthetic compounds have interesting pharmacological properties. In addition to these pharmacological properties, different derivatives of pyridones have been reported to have several biological activities such as antiviral [1], antifungal [2], antibacterial [3] and antitumor [4, 5]. Some derivatives of 2-pyridone were recognized as potential HIV-1 specific transcriptase inhibitor. These can also be used as cardiotonic agents for the treatment of heart problems. These compounds play role of important intermediates in the synthesis of polycyclic compounds [2, 4, 5]. The electronic absorption and fluorescence spectra of a molecule are greatly affected by the presence of nature of solvents [6–8]. Existence of specific and non-specific interaction between solute and solvents
* Ranjana Singh [email protected] * Ranjan K. Singh [email protected] 1
Department of Physics, Institute of Science, Banaras Hindu University, Varanasi 221005, India
2
Department of Physics, Mahatma Gandhi Kashi Vidyapith, Varanasi 221001, India
3
Department of Botony, Institute of Science, Banaras Hindu University, Varanasi 221005, India
are responsible for change in molecular geometry, dipole moment of the solute and its electronic structure. Solvent dependent properties of UV-Visible absorption spectra have made this technique very important to study solute-solvent interactions. This property originates from the fact that many electronic properties such as multipole moments and polarizabilities of the ground state and excited state are not identical [8]. In one of our previous work the CDPy molecule was synthesized and characterized successfully using various spectroscopic techniques such as 1H-NMR, 13C-NMR, FTIR, Raman, UV-Visible absorption and steady state fluorescence [9]. The CDPy was further used as a selective, stable and reproducible fluorescent probe for Hg+2 ions detection in the river water [9]. In the present work the photophysical p
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