Statins not associated with intracerebral haemorrhage
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Statins not associated with intracerebral haemorrhage No association between statin use after ischaemic stroke and subsequent intracerebral haemorrhage (ICH) was found in a retrospective Canadian study. The study included 17 872 elderly patients admitted for acute ischaemic stroke between July 1994 and March 2008 in Ontario: 8936 of the patients were treated with statins and 8936 controls were not treated with statins. During up to 5 years of follow-up, 213 episodes of ICH occurred. No increased risk of ICH was found in statin users compared with non-users (hazard ratio 0.87; 95% CI 0.65, 1.17). This lack of harmful association was consistent across different analytic techniques, subgroup analyses, and with different dosages of statins. Based on these findings, the study researchers conclude that "physicians should continue to adhere to current treatment guidelines recommending statin therapy for most patients with a history of ischemic stroke." However, they advise caution when considering statin therapy in patients with a history of ICH. Hackam DG, et al. Statins and Intracerebral Hemorrhage - A Retrospective Cohort Study. Archives of Neurology : [7 pages], 14 Sep 2011. Available from: URL: 801161091 http://www.archneurol.com
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