Sulfonylureas overdose
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Sulfonylureas overdose Hypoglycaemic symptoms: 8 case reports
Eight women with diabetes mellitus, aged between 38 and 74 years, accidentally ingested supratherapeutic doses of tolazamide (patients 1, 3 and 8), glibenclamide (patients 2, 5 and 7), glimepiride (patient 4) or glipizide (patient 6) and developed symptoms of hypoglycaemia. These cases are from a retrospective review of calls made to a poison control centre from 2000–2003. After ingesting supratherapeutic doses of sulfonylureas, patients reported feeling dizzy (patients 1, 3, 5 and 6), shaky (patients 2, 7 and 8) and clammy (patient 4) [time to reaction onsets not stated]. None of the patients had blood glucose levels of < 60 mg/dL [see table]. All patients ingested carbohydrate or glucose supplementation at home. Subsequently, all the patients experienced resolution of symptoms.
Patient characteristics Patient Sex/ Dose age ingested (years) (mg) 1 2 3 4 5 6 7 8
F/62 F/38 F/69 F/50 F/74 F/49 F/57 F/59
1000 10 500 8 20 5 20 750
Usual dose (mg)/usual daily dose (mg)
Lowest blood sugar levela /time drawn (hours)
500/1000 2.5/7.5 250/250 4/4 10/10 2.5/NS 10/15 250/500
108/7 113/9 125/6 134/4 149/6 NS NS NS
units not stated NS not stated
a
Cantrell FL, et al. Supratherapeutic doses of sulfonylureas in diabetic patients: how much is too much? Clinical Toxicology 45: 482-484, No. 5, Jun-Aug 2007 801091567 USA
0114-9954/10/1173-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 13 Oct 2007 No. 1173
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