Synchronous hepatocellular carcinoma and gallbladder adenocarcinoma with neuroendocrine differentiation: a case report a
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CASE REPORT
Synchronous hepatocellular carcinoma and gallbladder adenocarcinoma with neuroendocrine differentiation: a case report and literature review Yan Xu, Quan‑Ning Chen, Hui Wang, Nan‑Bin Liu and Bao‑Min Shi*
Abstract Background: Double primary cancers have a low incidence rate, and synchronous hepatocellular carcinoma and gallbladder adenocarcinoma are rarely reported. Here, we report such a case— the 12th case of synchronous double primary cancers featuring HCC and GC, but the first case of neuroendocrine differentiation in the gallbladder. Case presentation: A 77-year-old female was admitted to the hospital complaining of weakness and inappetence for six months. Contrast-enhanced computed tomography (CT) of the abdomen indicated an 11 cm space-occu‑ pying lesion in the right lobe of the liver. Later, magnetic resonance imaging showed a high possibility of a massive hepatoma, and multiple gallstones were also seen. After transhepatic arterial chemoembolization, a repeat abdominal CT showed obvious local nodular thickening in the gallbladder wall. Finally, resection of the right lobe of the liver and cholecystectomy were performed. During an approximately 2-year follow-up, the patient recovered uneventfully without recurrence or metastasis. Conclusion: The disease in this case is rare and lacked typical radiological features. More precise and advanced diag‑ nostic techniques are needed to obtain a clear diagnosis and refine treatment strategies. The management strategy should always be curative, even in the presence of multiple malignancies. Keywords: Hepatocellular carcinoma, Gallbladder cancer, Synchronous double primary cancer, Case report Background Multiple primary cancers (MPCs) refer to two or more kinds of malignancies occurring in the same or different organs, with unknown pathogeneses. MPC involving both the liver and gallbladder is rarely reported, and only 15 cases have been recorded, with 11 cases histologically proven as hepatocellular carcinoma (HCC) and gallbladder adenocarcinoma (GC). Here, we present the 12th case of synchronous double primary cancers featuring
*Correspondence: [email protected] Department of General Surgery, Tongji Hospital, Tongji University Medical School, Shanghai 200065, People’s Republic of China
HCC and GC, but the first case of neuroendocrine differentiation in the gallbladder.
Case presentation In 2017, a 77-year-old retired female patient was admitted to our hospital, which serves as an outpatient hospital, with only complaints of weakness and inappetence for 6 months. A contrast-enhanced CT indicated an 11 cm space-occupying lesion in the right lobe of the liver. There was no particular family history or infectious medical history. She did not receive any medical intervention before admission, and her vital signs, such as blood pressure, heart rate, respiration rate and body temperature, were normal. Physical examination showed
© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 Inter
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