Synthesis and application of magnetic@layered double hydroxide as an anti-inflammatory drugs nanocarrier
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Journal of Nanobiotechnology Open Access
RESEARCH
Synthesis and application of magnetic@layered double hydroxide as an anti‑inflammatory drugs nanocarrier Vahid Yousefi1†, Vahideh Tarhriz1†, Shirin Eyvazi2 and Azita Dilmaghani3,4*
Abstract Background: Magnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier. Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery. Keywords: Layered double hydroxide, Nanostructure, Iron oxide nanoparticle, Anti-inflammatory drugs, Drug delivery Background In recent years, magnetic nanocomposites with a core– shell nanostructure have attracted increasing attention because of their exclusive physical and chemical *Correspondence: [email protected] † Vahid Yousefi and Vahideh Tarhriz contributed equally to this work and should be considered as co-first authors 4 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Full list of author information is available at the end of the article
properties and huge possible applications in different areas such as extraction, the release of drug, medicine, mechanical aspects, etc. [1–5]. Several performanceparticulars with high surface shells have been prepared so far on the iron oxide nanospheres, significantly growing the magnetic core@shell nanostructure area [6–8]. Inorganic nanomaterials are commonly used because of their low cost, high surface area, easy availability, and easy preparation. Layered double hydroxides (LDHs),
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