Synthesis and self-assembly behavior of a biodegradable and sustainable soybean oil-based copolymer nanomicelle
- PDF / 1,128,772 Bytes
- 6 Pages / 595.276 x 793.701 pts Page_size
- 8 Downloads / 169 Views
NANO EXPRESS
Open Access
Synthesis and self-assembly behavior of a biodegradable and sustainable soybean oil-based copolymer nanomicelle Lixia Bao1,2, Longchun Bian2, Mimi Zhao2, Jingxin Lei1 and Jiliang Wang2*
Abstract Herein, we report a novel amphiphilic biodegradable and sustainable soybean oil-based copolymer (SBC) prepared by grafting hydrophilic and biocompatible hydroxyethyl acrylate (HEA) polymeric segments onto the natural hydrophobic soybean oil chains. FTIR, H1-NMR, and GPC measurements have been used to investigate the molecular structure of the obtained SBC macromolecules. Self-assembly behaviors of the prepared SBC in aqueous solution have also been extensively evaluated by fluorescence spectroscopy and transmission electron microscopy. The prepared SBC nanocarrier with the size range of 40 to 80 nm has a potential application in the biomedical field. Keywords: Soybean oil; Self-assembly; Nanomicelle; Biomaterials
Background Many efforts have been done to develop biodegradable biomaterials during the past 2 decades due to their large potential application in biomedical fields of tissue engineering, gene therapy, regenerative medicine, controlled drug delivery, etc. [1-3]. There are many factors to choose biodegradable rather than biostable materials for biomedical applications. The main driving forces are the long-term biocompatibility issues with many of the existing permanent implants and many levels of ethical and technical issues associated with revision surgeries [4]. The recent research interest about biomaterials focuses on designation and development of novel biodegradable polymers and related derivates, including polyesters [5-7], polylactides [8], polycaprolactones [9-11], poly(ester amide)s [12,13], polyanhydrides [14-16], polyurethanes [17-20], and so on. Unfortunately, most of the reported main raw materials used to synthesize biodegradable polymers are unsustainable petroleum-based compounds. As the global demand for petroleum-based plastics continues to increase, unstable crude oil price and related environmental problems have triggered a search for replacing these non-biodegradable and unsustainable * Correspondence: [email protected] 2 School of Chemical Science and Technology, Yunnan University, Kunming 650091, China Full list of author information is available at the end of the article
plastics. Development and application of biodegradable and sustainable plant-based products such as natural oils may be the most promising choice to solve these problems. For example, Thamae et al. [21] have developed a biodegradable corn stover filled polyethylene biomaterials. The effect of the corn stover size and the content and the morphology of the filler on the structure and mechanical properties of the obtained biocomposites have been extensively evaluated. Recently, our group has also developed a novel nontoxic, biodegradable, and ionconductive plasticizer based on natural citric acid for soft poly(vinyl chloride) composites [22]. Soybean oil is one of the most widely available biodegra
Data Loading...
