Synthesis, structure and antioxidant properties of manganese(II), zinc(II) and cobalt(II) complexes with bis(benzimidazo
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Synthesis, structure and antioxidant properties of manganese(II), zinc(II) and cobalt(II) complexes with bis(benzimidazol‑2‑ylmethyl) allylamine Cong Wang1 · Yancong Wu1 · Yao Qu1 · Kun Zhao1 · Jianhua Xu1 · Xinzhao Xia1 · Huilu Wu1 Received: 6 April 2020 / Accepted: 2 June 2020 © Springer Nature Switzerland AG 2020
Abstract Three new metal complexes, namely: [Mn(AIDB)Cl2]·DMF (1), [Zn(AIDB)Br2]·CH3OH (2) and [Co(AIDB)Cl2]·CH3OH (3) having a ligand bis(benzimidazol-2-ylmethyl)allylamine (AIDB), have been synthesized in high yields and characterized by elemental analyses, molar conductivities, IR, UV–Vis spectra and single-crystal X-ray diffraction. The structural analysis revealed that all the three complexes 1–3 have five-coordinated trigonal bipyramid geometry where the degree of distorting is 1>3>2. In vitro antioxidant activity assay demonstrates that the complexes 1 and 3 display high scavenging activity against hydroxyl (OH·) and superoxide (O2−·) radicals.
Introduction Since antioxidants have the advantage of protecting the human body from reactive oxygen species (ROS); research on antioxidant free radicals has received extensive attention in recent years [1–8]. Reactive oxygen species such as hydroxyl radicals (OH−·) and superoxide anion radicals (O2−·) are major factors in the process of exacerbating cell damage and aging process [9–11], which mainly act in the body by targeting unsaturated fatty acids in bio membranes, and cause membrane lipid peroxidation (a hallmark of hepatotoxicity), decrease membrane fluidity, suppress enzyme and receptor activity and damage membrane proteins, which finally triggers cell inactivation and death [12–14]. Although the human body has an enzyme and non-enzymatic antioxidant defense mechanism, it is impossible for the body to clear all ROS [15]. Excessive ROS in the human body could induce more than 200 diseases such as various cardiovascular diseases, neurological diseases and tumors, and also Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11243-020-00405-9) contains supplementary material, which is available to authorized users. * Huilu Wu [email protected] 1
cause tissue and organ aging, nephritis and rheumatism [16]. Free radical scavenging is one of the major antioxidation mechanisms inhibiting the chain reaction of lipid peroxidation. Antioxidant capacity can be reflected by the ability to inhibit or remove free radicals. Hence, the investigation of antioxidant compounds that prevent or reduce the effects of ROS on cells is an increasingly significant area of research [17]. Benzimidazole derivatives are an important class of nitrogen-containing heterocyclic compounds and have a wide range of applications in medicinal chemistry, coordination chemistry, photochemistry and bioinorganic chemistry [18, 19], exhibiting excellent biological and pharmaceutical activities including antibacterial, antiviral, antioxidant, anti-HIV and anticancer drugs.[20–23]. Studies have shown that many transition metal complexes als
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