Systems Analysis of Human Multigene Disorders
Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementi
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Natalia Maltsev Andrey Rzhetsky T. Conrad Gilliam Editors
Systems Analysis of Human Multigene Disorders
Advances in Experimental Medicine and Biology Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy
For further volumes: http://www.springer.com/series/5584
Natalia Maltsev • Andrey Rzhetsky T. Conrad Gilliam Editors
Systems Analysis of Human Multigene Disorders
Editors Natalia Maltsev Department of Human Genetics Institute for Genomics and Systems Biology, Computation Institute The University of Chicago Chicago, IL, USA
Andrey Rzhetsky Deapartment of Medicine Department of Human Genetics Institute for Genomics and Systems Biology, Computation Institute The University of Chicago Chicago, IL, USA
T. Conrad Gilliam Department of Human Genetics Institute for Genomics and Systems Biology, Computation Institute The University of Chicago Chicago, IL, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) ISBN 978-1-4614-8777-7 ISBN 978-1-4614-8778-4 (eBook) DOI 10.1007/978-1-4614-8778-4 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013952921 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect
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