T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve
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RESEARCH ARTICLE
T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression Nico Sollmann1,2 · Dominik Weidlich3 · Elisabeth Klupp1 · Barbara Cervantes3 · Carl Ganter3 · Claus Zimmer1,2 · Ernst J. Rummeny3 · Thomas Baum1 · Jan S. Kirschke1,2 · Dimitrios C. Karampinos3 Received: 15 August 2019 / Revised: 22 December 2019 / Accepted: 28 January 2020 © The Author(s) 2020
Abstract Objective To measure T2 values for magnetic resonance neurography (MRN) of the healthy distal sciatic nerve and compare those to T2 changes in patients with nerve compression. Materials and methods Twenty-one healthy subjects and five patients with sciatica due to disc herniation underwent MRN using a T2-prepared turbo spin echo (TSE) sequence of the distal sciatic nerve bilaterally. Six and one of those healthy subjects further underwent a commonly used multi-echo spin-echo (MESE) sequence and magnetic resonance spectroscopy (MRS), respectively. Results T2 values derived from the T2-prepared TSE sequence were 44.6 ± 3.0 ms (left) and 44.5 ± 2.6 ms (right) in healthy subjects and showed good inter-reader reliability. In patients, T2 values of 61.5 ± 6.2 ms (affected side) versus 43.3 ± 2.4 ms (unaffected side) were obtained. T2 values of MRS were in good agreement with measurements from the T2-prepared TSE, but not with those of the MESE sequence. Discussion A T2-prepared TSE sequence enables precise determination of T2 values of the distal sciatic nerve in agreement with MRS. A MESE sequence tends to overestimate nerve T2 compared to T2 from MRS due to the influence of residual fat on T2 quantification. Our approach may enable to quantitatively assess direct nerve affection related to nerve compression. Keywords Magnetic resonance spectroscopy · Peripheral nervous system diseases · Sciatica · Spine Abbreviations 2D Two-dimensional 3D Three-dimensional a.u. Arbitrary units BMRC British Medical Research Council
CIDP Chronic inflammatory demyelinating polyneuropathy CMTD Charcot–Marie–Tooth disease DTI Diffusion tensor imaging FOV Field of view LSP Lumbosacral plexus
* Nico Sollmann [email protected]
Jan S. Kirschke [email protected]
Dominik Weidlich [email protected]
Dimitrios C. Karampinos [email protected]
Elisabeth Klupp [email protected]
1
Carl Ganter [email protected]
Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
2
Claus Zimmer [email protected]
TUM‑Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
3
Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Ernst J. Rummeny [email protected] Thomas Baum [email protected]
13
Vol.:(0123456789)
MRI Magnetic resonance imaging MRN Magnetic resonance neurography MRS Magnetic resonance spectroscopy MS Multiple sclerosis MESE Multi-echo
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