The Biology of Senescence A Translational Approach

This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and p

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Bernard Swynghedauw

The Biology of Senescence A Translational Approach

Practical Issues in Geriatrics Series Editor Stefania Maggi Aging Branch CNR-Neuroscience Institute Padua  Italy

This practically oriented series presents state of the art knowledge on the principal diseases encountered in older persons and addresses all aspects of management, including current multidisciplinary diagnostic and therapeutic approaches. It is intended as an educational tool that will enhance the everyday clinical practice of both young geriatricians and residents and also assist other specialists who deal with aged patients. Each volume is designed to provide comprehensive information on the topic that it covers, and whenever appropriate the text is complemented by additional material of high educational and practical value, including informative video-clips, standardized diagnostic flow charts and descriptive clinical cases. Practical Issues in Geriatrics will be of value to the scientific and professional community worldwide, improving understanding of the many clinical and social issues in Geriatrics and assisting in the delivery of optimal clinical care. More information about this series at http://www.springer.com/series/15090

Bernard Swynghedauw

The Biology of Senescence A Translational Approach

Bernard Swynghedauw French Institute of Health and Medical Research Paris France

ISSN 2509-6060     ISSN 2509-6079 (electronic) Practical Issues in Geriatrics ISBN 978-3-030-15110-2    ISBN 978-3-030-15111-9 (eBook) https://doi.org/10.1007/978-3-030-15111-9 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Acknowledgment

Firstly, the author wishes to give many tha