The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer pati
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The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients Cynthia S. Bonhof 1,2 & Lonneke V. van de Poll-Franse 1,2,3 & Dareczka K. Wasowicz 4 & Laurens V. Beerepoot 5 & Gerard Vreugdenhil 6 & Floortje Mols 1,2 Received: 26 May 2020 / Accepted: 31 July 2020 # The Author(s) 2020
Abstract Purpose To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on healthrelated quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQC30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results Among chemotherapy-treated patients (n = 105), a high sensory peripheral neuropathy (SPN) level was reported by 57% of patients at 1 year, and 47% at 2-year follow-up, whereas a high motor peripheral neuropathy (MPN) level was reported by 47% and 28%, at years 1 and 2, respectively. Linear mixed model analyses showed that SPN and MPN symptoms significantly increased from baseline to 1-year follow-up and did not return to baseline level after 2 years. Patients with a high SPN or MPN level reported a worse global quality of life and a worse physical, role, emotional, cognitive, and social functioning compared with those with a low SPN or MPN level. Conclusions Future studies should focus on understanding the mechanisms underlying CIPN so targeted interventions can be developed to reduce the impact of CIPN on patient’s lives. Implications for cancer survivors Patients need to be informed of both CIPN and the impact on HRQoL. Keywords Peripheral neuropathy . Colorectal cancer . Health-related quality of life . PROFILES
Abbreviations PROFILES Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship PROs Patient-reported outcomes NCR Netherlands Cancer Registry HRQoL Health-related quality of life CIPN Chemotherapy-induced peripheral neuropathy
PN SPN MPN MPN CRC
* Cynthia S. Bonhof [email protected]
3
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
4
Department of Surgery, Elisabeth-TweeSteden hospital, Tilburg, the Netherlands
5
Department of Internal Medicine, Elisabeth-TweeSteden hospital, Tilburg, the Netherlands
6
Department of Internal Medicine, Máxima Medical Centre, Eindhoven and Veldhoven, The Netherlands
1
2
Department of Medical and Clinical Psychology, CoRPS - Center of Research on Psychology in Somatic disorders, Tilburg University, Tilburg, The Netherlands Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands
Peripheral neuropathy Sensory peripheral neuropathy Motor peripheral neuropathy Autonomic peripheral neuropath
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