The effect of l -carnitine supplementation on serum leptin concentrations: a systematic review and meta-analysis of rand
- PDF / 619,732 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 4 Downloads / 131 Views
META-ANALYSIS
The effect of L-carnitine supplementation on serum leptin concentrations: a systematic review and meta-analysis of randomized controlled trials Ali Nazary-vannani1 Ehsan Ghaedi1 Seyed Mohammad Mousavi1 Alireza Teymouri2 Jamal Rahmani3 Hamed Kord Varkaneh1 ●
●
●
●
●
1234567890();,:
Received: 15 December 2017 / Accepted: 2 February 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018
Abstract Purpose The actual effects of L-carnitine administration on leptin serum level is inconsistent. In order to assess the efficacy of L-carnitine supplementation on serum leptin we conducted a meta-analysis of randomized controlled trials (RCTs). Methods Seven studies with 325 cases and 330 controls were included. The pooled weighted mean difference (WMD) was calculated by random-effects model. The heterogeneity across studies was evaluated by using Cochrane’s Q and I2 tests. In addition, we carried out the metaninf command to test the effect of each individual study on the overall result. Results L-carnitine supplementation seemed to have no significant effect on serum leptin concentrations (WMD: −0.565 ng/mL; 95% CI: −2.417 to 1.287, p = 0.550). However, between-study heterogeneity was higher across all studies (I2 = 84.3%, p < 0.0001). Subgroup analysis to find the sources of heterogeneity showed that L-carnitine dosage (g) ( < 2 g: I2 = 00.0%, p = 0.408), and study population (diabetes: I2 = 46.7%, p = 0.153, and non-diabetes: I2 = 15.1%, p = 0.317) were the potential sources of heterogeneity. Besides, a more significant reduction in serum leptin concentration was observed with a daily dose of ≥ 2 mg L-carnitine (WMD: −2.742 ng/mL; 95% CI: −3.039 to −2.444, p < 0.001), in diabetic patients (WMD: −2.946 ng/mL; 95% CI: −3.254 to −2.638, p < 0.001), and with intervention duration
Data Loading...
