The IgG galactosylation ratio is higher in spondyloarthritis patients and associated with the MRI score
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ORIGINAL ARTICLE
The IgG galactosylation ratio is higher in spondyloarthritis patients and associated with the MRI score Jing Liu 1,2 & Qi Zhu 3 & Jing Han 4 & Hui Zhang 1 & Yuan Li 1,2 & Yanyun Ma 2,5 & Hengdong Ji 6 & Dongyi He 3 & Jianxin Gu 4 & Xiaodong Zhou 7 & John D. Reveille 7 & Li Jin 1,2 & Hejian Zou 8,9 & Shifang Ren 4 & Jiucun Wang 1,2,9 Received: 24 July 2019 / Revised: 27 November 2019 / Accepted: 14 February 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Objectives MRI is an important tool for evaluating inflammation levels and assessing treatment response in patients with ankylosing spondylitis (AS). However, it is expensive and requires experienced physicians. The goal of this study was to identify a biomarker correlated with the MRI score. Methods A total of 558 spondyloarthritis (SpA) patients including 527 AS patients, 10 psoriasis (PsA) patients, and 21 non-radiographic SpA (nr-SpA) patients and 725 controls were enrolled for the studies. Plasma IgG galactosylation (IgG-Gal) level was measured by mass spectrometry. Clinical indexes such as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and C-reactive protein (CRP) were measured in all AS patients. MRIs and X-rays were obtained from 65 AS patients who were followed up for 6 months. Results The IgG-Gal ratio was twice as high in the AS patients compared with the controls. It correlated with inflammation indices which is evaluated by MRI according to SPARCC. (Pearson coefficient/p value was 0.6/7E10−6). In addition, AS patients with a higher IgG-Gal ratio at baseline tended to show greater improvement in inflammation scores by MRI both in 3-month follow-up and 6-month follow-up. Conclusion The IgG-Gal ratio was significantly increased in AS patients. In clinical care, it may be used as a potential biomarker for diagnosis in the future. Key Points • IgG galactosylation level was abnormal in SpA patients. • IgG galactosylation level was associated with MRI indices.
Keywords IgG galactosylation ratio . MRI score . Spondyloarthritis Jing Liu, Qi Zhu and Jing Han contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10067-020-04998-5) contains supplementary material, which is available to authorized users. * Hejian Zou [email protected]
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Department of Biochemistry and Molecular Biology, Key Laboratory of Glycoconjugate Research Ministry of Public Health, School of Basic Medical Sciences, Fudan University, Shanghai, China
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Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China
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State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China
Division of Rheumatology, Taizhou People’s Hospital, Taizhou, Jiangsu Province, China
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Division of Rheumatology and Clinical Immunogenetics, The University of Tex
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