The joint association of diabetes distress and depressive symptoms with all-cause mortality in Japanese individuals with
- PDF / 594,688 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 10 Downloads / 165 Views
ARTICLE
The joint association of diabetes distress and depressive symptoms with all-cause mortality in Japanese individuals with type 2 diabetes: a prospective cohort study (Diabetes Distress and Care Registry in Tenri [DDCRT 20]) Yasuaki Hayashino 1 & Shintaro Okamura 1 & Satoru Tsujii 1 Registry at Tenri Study Group
&
Hitoshi Ishii 2
&
for the Diabetes Distress and Care
Received: 28 July 2020 / Accepted: 31 July 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Aims/hypothesis The independent association of depressive symptoms and diabetes distress with mortality risk in individuals with diabetes has not been evaluated. We examined the temporal joint association of diabetes distress and depressive symptoms at baseline and the subsequent risk of all-cause mortality. Methods The longitudinal data of 3118 individuals with type 2 diabetes were obtained from a large Japanese diabetes registry. To assess the joint association of diabetes distress and depressive symptoms at baseline with the subsequent risk of all-cause mortality, the Cox proportional hazards model was used with adjustment for potential confounders. Results The mean age, BMI and HbA1c levels were 64.7 years, 24.6 kg/m2 and 58.6 mmol/mol (7.5%), respectively, and 38.1% of the participants were women. In the multivariable-adjusted models evaluating the diabetes distress and depressive symptoms separately, the HRs for all-cause mortality were 1.67 (95% CI 1.14, 2.43; p = 0.008) and 1.40 (95% CI 1.05, 1.85; p = 0.020), respectively. In such models evaluating the joint association of diabetes distress and depressive symptoms, compared with individuals without diabetes distress or depressive symptoms (DD−/DS−), the HRs for all-cause mortality for the group without diabetes distress but with depressive symptoms (DD−/DS+), with diabetes distress but without depressive symptoms (DD+/DS−), and with diabetes distress and depressive symptoms (DD+/DS+) were 1.34 (95% CI 0.99, 1.86; p = 0.056), 1.96 (95% CI 1.10, 3.50; p = 0.023) and 1.71 (95% CI 1.06, 2.77; p = 0.029), respectively. We did not observe a significant interaction between diabetes distress and depressive symptoms with all-cause mortality risk (p = 0.2636). In the stratified analysis by sex, a significant joint association of diabetes distress and depressive symptoms with the risk of all-cause mortality was observed only in men. Conclusions/interpretation Diabetes distress and depressive symptoms were independently associated with all-cause mortality risk in male participants with type 2 diabetes, but we did not observe a significant interaction between diabetes distress and depressive symptoms in relation to all-cause mortality.
Keywords Depressive symptom . Diabetes distress . Epidemiology . Human . Mortality risk . Patient-reported outcome . Type 2 diabetes
Members of the Diabetes Distress and Care Registry at Tenri Study Group are listed in the Appendix. * Yasuaki Hayashino [email protected] 1
Department of Endocrinology, Tenri Hospital, Tenri, Nara, Japan
2
Dep
Data Loading...
