The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this serie
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The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems Contributors 1.A. Angus, 1.w. Black, A.1. Barr, R.A. Bond, M. Bouvier, M. Corsi, T. Costa, s. Cotecchia, D.M. Ignar, C.K. Jayawickreme, S.S. Karnik, AJ. Kaumann, T. Kenakin, S.M. Lanier, MJ. Lew, M.R. Lerner, 1.1. Linderman, M. Lutz, D.R. Manning, G. Milligan, P. Morgan, R.G. Onaran, D.M. Perez, S. Rees, A. Scheer, D.G. Trist, 1. Weiss, R.T. Windh
Editors:
T. Kenakin and IA. Angus
i
Springer
TERRY KENAKIN, Ph.D. Principal Research Scientist Department of Receptor Biochemistry Glaxo Wellcome Research and Development
5 Moore
Drive
Research Triangle Park,
NC 27709
USA e-mail: [email protected] Professor JAMES
A. ANGus, Ph.D. FAA
Head, Department of Pharmacology The University of Melbourne Parkville, VIC 3010 AUSTRALIA e-mail: [email protected] With 132 Figures and 20 Tables
ISBN 978-3-642-63028-6 Library of Congress Cataloging-in-Publication Data The pharmacology of functional, biochemical, and recombinant receptor systems / contributors, J.A. Angus ... [et aL]; editors, T. Kenakin and J.A. Angus. p. cm. - (Handbook of experimental pharmacology; v. 148) IncIudes bibliographical references and index. ISBN 978-3-642-63028-6 ISBN 978-3-642-57081-0 (eBook) DOI 10.1007/978-3-642-57081-0 1. Drug receptors - Research - Methodology 1. Kenakin, Terrence P. II. Angus, James A. III. Series. [DNLM: 1. Receptors, Drug - physiology. 2. Dose-Response Relationship, Drug. 3. Pharmaceutical Preparations -metabolism. 4. Receptors, CeII Surface - drug effects. 5. Technology, Pharmaceutical methods. QV 38 P5367 2000] QP905.H3 voI. 148 [RM301.41] 615'.7 - dc21 00-036585 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specificaIIy the rights of translation, reprinting re-use of iIIustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-VerIag. Violations are liable for Prosecution under the German Copyright Law.
© Springer-Veriag Berlin Heidelberg 2000 Origina11y published by Springer-Veriag Berlin Heideiberg in 2000 Softcover reprint ofthe hardcover Ist edition 2000
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