Timing and variability of late myocardial enhancement imaging in anesthetised pediatric patients
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BioMed Central
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Poster presentation
Timing and variability of late myocardial enhancement imaging in anesthetised pediatric patients Edythe B Tham*, Kimberley Myers, Cinzia Crawley, Ryan W Hung and Michelle L Noga Address: University of Alberta, Edmonton, AB, Canada * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P25
doi:10.1186/1532-429X-12-S1-P25
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P25 © 2010 Tham et al; licensee BioMed Central Ltd.
Introduction Current protocols for late enhancement imaging using adult techniques do not achieve adequate nulling in children. Young children have faster heart rates, smaller blood volumes and faster circulation. We hypothesize that the timing for late enhancement imaging in adults is not applicable to children.
Purpose The aim of this study was to determine the best timing for late enhancement imaging in anesthetised children.
the anatomy in congenital heart disease (n = 7) or function in cardiomyopathy (n = 5). One patient with a cardiomyopathy had positive enhancement in the RV free wall with the rest being negative. There was good agreement between observers for scout images at 2 (κ = 0.69) & 3 (κ = 0.66) minutes and a moderate agreement at 4 min (κ = 0.57). Agreement of PSIR images was moderate at 7 min (κ = 0.44) and poor-fair at other times. Linear regression analysis showed a significant correlation between TI and scout time (r = 0.61, p < 0.0001). The mean increase in TI from the 4-10 min scout was 50 ± 15 msec. There was no
Methods Sedated cardiac MRI was performed on a 1.5 T Siemens Sonata. After IV injection of 0.2 mmol/kg of gadolinium (Magnovist), scout images were obtained at 2, 3, 4 and 10 minutes, and turboFLASH PSIR were obtained using standard views at 5-9 minutes. All images were assessed according to a grading score: 0 = none; 1 = reverse; 2 = poor; 3 = partial; and 4 = good nulling. The inversion time (TI) was determined from the best nulled scout image. Images were analysed by 3 independent observers blinded to the clinical information. The mean and standard deviation of the grading score was analysed using the KruskalWallis analysis and interobserver variability was determined by quadratic weighted kappa statistics.
Results Twelve children at a median age of 12 months (range: 160) were studied. The indication for MRI was to evaluate
Figureof1scout time on inversion time Effect Effect of scout time on inversion time.
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Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P25
http://jcmr-online.com/content/12/S1/P25
Table 1: Grading score
Grade
Degree of nulling
Myoca
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