Towards a Twenty-First-Century Pedagogy for the Humanities
The concept of digital epistemology discussed here suggests that the historical curriculum should be revised, since “the digital”—understood as a perspective or a lens (Lindhé 2013 ; O’Gorman, Marcel, E-Crit: Digital Media, Critical Theory and The Humanit
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Relation between Thyroid Function and Mortality in patients with Chronic Heart Failure Nathan A. Samuel BSc , Joseph J. Cuthbert MD , Oliver I. Brown MBBS , Syed Kazmi MS , John G.F. Cleland PhD , Alan S. Rigby CStat , Andrew L. Clark MD PII: DOI: Reference:
S0002-9149(20)31140-1 https://doi.org/10.1016/j.amjcard.2020.10.034 AJC 24924
To appear in:
The American Journal of Cardiology
Received date: Revised date: Accepted date:
21 August 2020 9 October 2020 12 October 2020
Please cite this article as: Nathan A. Samuel BSc , Joseph J. Cuthbert MD , Oliver I. Brown MBBS , Syed Kazmi MS , John G.F. Cleland PhD , Alan S. Rigby CStat , Andrew L. Clark MD , Relation between Thyroid Function and Mortality in patients with Chronic Heart Failure, The American Journal of Cardiology (2020), doi: https://doi.org/10.1016/j.amjcard.2020.10.034
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Highlights
Subclinical thyroid dysfunction is very common in patients with chronic heart failure (~10%) There is a U-shaped relation between Thyroid-Stimulating Hormone and mortality Subclinical hypothyroidism is associated with worse outcome in univariable analysis, but the association disappears after adjustment for age and natriuretic peptide level There is a weak but significant association between increasing Thyroid-Stimulating Hormone and outcome in patients with heart failure with normal ejection fraction
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Relation between Thyroid Function and Mortality in patients with Chronic Heart Failure Nathan A. Samuel, BSc,1* Joseph J. Cuthbert, MD,2 Oliver I. Brown, MBBS,2 Syed Kazmi MS,2 John G. F. Cleland, PhD,3 Alan S. Rigby, CStat,1 Andrew L. Clark, MD.2 1
Hull York Medical School, University of Hull, UK
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Department of Academic Cardiology, Hull York Medical School, Hull and East Yorkshire Medical
Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull, UK 3
Robertson Institute of Biostatistics and Clinical Trials Unit, University of Glasgow, Glasgow, UK
Corresponding Author Nathan A. Samuel, Department of Academic Cardiology, Hull York Medical School, Hull and East Yorkshire Medical Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull UK Tel: +44 1482 461776 Fax: +44 1482 461776 Email: [email protected]
Declarations of Interest None.
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ABSTRACT Thyroid dysfunction is common in patients with chronic heart failure (CHF), but there is conflicting evidence regarding its prognostic significance. We investigate
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