Transient Receptor Potential (TRP) Channels

In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe propertie

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Volume 179 Editor-in-Chief K. Starke, Freiburg i. Br. Editorial Board G.V.R. Born, London S. Duckles, Irvine, CA M. Eichelbaum, Stuttgart D. Ganten, Berlin F. Hofmann, München W. Rosenthal, Berlin G. Rubanyi, San Diego, CA

Transient Receptor Potential (TRP) Channels Contributors J. Abramowitz, G.P. Ahern, I.S. Ambudkar, K.S. Authi, G.J. Barritt, D.J. Beech, R.J.M. Bindels, L. Birnbaumer, M. Bödding, K.A. del Carmen, A. Cavalié, C.K. Colton, A. Dietrich, P. Eder, J. Eisfeld, A. Fleig, V. Flockerzi, J. García-Añoveros, D.L. Gill, D. Griesemer, K. Groschner, T. Gudermann, L.-P. He, T. Hewavitharana, J.G.J. Hoenderop, M. Hoth, D.A. Jacobson, J.-Y. Kim, K. Kiselyov, L. Lemonnier, W. Liedtke, E.R. Liman, P. Luncsford, A. Lückhoff, J.A. Matta, A.R. Mensenkamp, Y. Mori, S. Muallem, K. Nagata, B.A. Niemeyer, B. Nilius, T. Numaga, J. Oberwinkler, G. Owsianik, R.L. Patterson, R. Penner, S.E. Philipp, L.H. Philipson, S.C. Pingle, T.D. Plant, M. Poteser, J.W. Putney, F. Qin, A. Quintana, D. van Rossum, G.Y. Rychkov, E.C. Schwarz, D.M. Shin, J.T. Smyth, J. Soboloff, M. Spassova, A. Stokes, R. Strotmann, M. Tominaga, S. Tonner, M. Trebak, H. Turner, G. Vazquez, K. Venkatachalam, R. Vennekens, T. Voets, M. Wakamori, A.S. Wenning, U. Wissenbach, R. Witzgall, M.-J. Wolfs, W. Xu, X. Yao, E. Yildirim, J. Young Kim, J.P. Yuan, M.X. Zhu Editors

Veit Flockerzi and Bernd Nilius

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Prof. Dr. Veit Flockerzi Experimentele und Klinische Pharmakologie und Toxikologie der Universität des Saarlandes Gebäude 46 66421 Homburg Deutschland veit.fl[email protected]

Prof. Dr. Bernd Nilius Laboratorium voor Fysiologie Katholieke Universiteit Leuven Campus Gasthuisberg Herestraat 49 3000 Leuven België [email protected]

With 55 Figures and 19 Tables

ISSN 0171-2004 ISBN-10 3-540-34889-1 Springer Berlin Heidelberg New York ISBN-13 978-3-540-34889-4 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2007 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consul