Two Mn(II)-Organic Frameworks: Selective Detection of Fe 3+ Ion and Treatment Activity on Alcohol-Induced Cerebellar Atr
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Two Mn(II)-Organic Frameworks: Selective Detection of Fe3+ Ion and Treatment Activity on Alcohol-Induced Cerebellar Atrophy By Reducing ROS Accumulation in Brain En‑Jie Guan1 · Yan Xia1 · Jian Hu1 Received: 11 July 2020 / Revised: 14 August 2020 / Accepted: 28 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Under solvothermal reaction conditions, two new Mn(II)-containing meta-organic frameworks (MOFs) having the chemical formula of [Mn(bda) (L)·0.5H2O]n (1) and [Mn(Hdda)2(L)·4H2O)]n (2) were prepared via a mixed-ligand method using different aromatic dicarboxylic acids ligands ( H2bda = benzopheno-4,4-dicarboxylic acid, H2dda = 1,2-diethyl ether-4,4′-dibenzoic acid) and the flexible 1,3-di(1 h-imidazol-1-yl)propane (L). Meanwhile, it is further demonstrated that complex 1 with excellent water stability can be used for a promising sensor for Fe3+ ions in aqueous solution, which has good selectivity and sensitivity. For the treatment of the alcohol-induced cerebellar atrophy, the accumulation of reactive oxygen species (ROS) in purkinje cells was evaluated by 2′,7′-dichlorofluorescin diacetate (DCFH-DA) assay. Besides, through real time reverse transcription-polymerase chain reaction (RT-PCR), the relative expression of ROS related gene in purkinje cells was detected. Keywords MOFs · Water stability · Fe3+ detection · Alcohol-induced cerebellar atrophy
1 Introduction A new report from the World Health Organization estimates that more than 2 billion people drink alcoholic beverages in the world, and that 763 million people are diagnosed with alcohol-related diseases and disorders [1]. Ethanol and a series of intermediates metabolized in the body have direct or indirect toxic effects on the tissues and cells of the body. Chronic alcoholism refers to pathological changes in parenchymal organs and behavioral disorders caused by long-term and excessive alcohol consumption, leading to reduced brain weight, brain atrophy, decreased neuron and glial cell density in the frontal cortex and other brain regions [2, 3], and the lack of white matter and permanent cognitive dysfunction, but the specific mechanism of alcohol-induced cerebellar atrophy is still unclear. In recent years, the design and exploration of metalorganic frameworks (MOFs) have developed rapidly. The one reason is their multiple architectures including * Jian Hu [email protected] 1
Department of Psychiatry, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
interpenetrating networks and porous frameworks, and the another reason is their underlying applications in a lot of fields, such as gas separation and storage, magnetism as well as catalysis, etc. [4–9]. In addition, due to their the higher selectivity, the lower detection limit as well as excellent stability, the luminescent metal-organic frameworks (LMOFs) which is viewed as a chemical sensor for identifying biological-related molecules, explosive compounds, organic molecules and metal ions have drawn tremendo
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