Two-stage bone and meniscus allograft and autologous chondrocytes implant for unicompartmental osteoarthritis: midterm r
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ORIGINAL ARTICLE
Two‑stage bone and meniscus allograft and autologous chondrocytes implant for unicompartmental osteoarthritis: midterm results E. Álvarez‑Lozano1 · D. Luna‑Pizarro1,3 · G. Meraz‑Lares1,2 · R. Quintanilla‑Loredo1 · M. V. Cerdá‑García1,2 · F. Forriol4 Received: 15 October 2019 / Accepted: 12 August 2020 © Istituto Ortopedico Rizzoli 2020
Abstract Background We analyzed the clinical and radiographic evolution of patients with knee unicompartmental osteoarthritis and axis alteration and osteochondral lesions in the femoral condyle, treated with tibial plateau and meniscus allograft and cultured autologous chondrocyte implantation in the femur in two steps. Purpose To analyze the clinical results with the first patients treated with this two-stage technique to avoid knee prosthesis in patients with unicompartmental osteoarthritis. Material and methodology Sixteen patients, average age 56 years, were included in a cohort study. We performed an osteotomy with tibia plateau allograft, including the meniscus. In a second surgery, the chondrocyte fibrin scaffold was placed in the femur. Clinical symptoms and function were measured using KSSR and KOOS scores. Wilcoxon’s test was performed to compare the results over the 2-year follow-up period. Results Mean KSSR before surgery was 35.69 (SD: 3.75) points, rising to 67 (SD: 15.42) at 3 months, 95.88 at 12 months (SD: 2.68) and 96.31 at 24 months (SD: 2.24). The KOOS before surgery was 65.14 (SD: 16.34), rising to 72.68 after 3 months (SD: 19.15), 76.68 at 12 months (SD: 18.92) and 64.28 at 24 months (SD: 11.79). Four of 5 patients returned to engaging in the activity that they had stopped practicing. Three patients experienced collapse of the tibia allograft, and they needed later a prosthesis. Conclusions Simultaneous tibia plateau allograft and autologous chondrocyte implantation in the femur, after correction of the angular deformity, were performed, restoring the anatomy of the medial compartment and knee function in 82% of the patients 2 years after the operation. Level of evidence IV. Keywords Knee · Unicompartmental osteoarthritis · Meniscus allograft · Autologous chondrocyte implantation · Allogenic bone transplantation
1
E. Álvarez‑Lozano [email protected]
Department of Traumatology and Orthopedics, Hospital Universitario Dr. Jose E. González, Universidad Autónoma de Nuevo León (UANL), Monterrey, NL, Mexico
2
D. Luna‑Pizarro [email protected]
Department of Traumatology and Orthopedics, Medica Sur Private Hospital, Ciudad de México (CDMX), México
3
Department of Research Division, Mexican Institute of Social Security (IMSS), Hospital of Traumatology and Orthopedics “Lomas Verdes”, Médica Sur Private Hospital, Ciudad de México (CDMX), Mexico
4
Department of Clinical Sciences, School of Medicine, University CEU – San Pablo, Campus Monteprincipe, Madrid, Spain
* F. Forriol [email protected]
G. Meraz‑Lares [email protected] R. Quintanilla‑Loredo [email protected] M. V. Cerdá‑García Margia_2806@hot
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