Use of Pregabalin as Preemptive Analgesia for Decreasing Postoperative Pain in Tympanoplasty
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ORIGINAL ARTICLE
Use of Pregabalin as Preemptive Analgesia for Decreasing Postoperative Pain in Tympanoplasty Rajendra Kumar Teharia1
•
Vikram Singh Rathore2
Received: 11 August 2020 / Accepted: 26 September 2020 Ó Association of Otolaryngologists of India 2020
Abstract Tympanoplasty is a commonly performed surgical procedure done by Otorhinolaryngologist for treatment of chronic suppurative otitis media. Postoperative period requires the use of analgesics which are given regularly. The study aims to assess the efficacy of a single dose of preemptive pregabalin in decreasing postoperative pain after postauricular type 1 tympanoplasty. This randomized prospective study was carried out in a tertiary care hospital between July 2017 and April 2018. A total of 60 patients were divided into two groups of 30 each. This study analyzed the effect of single preoperative use of pregabalin 150 mg oral 1 h before type 1 postauricular tympanoplasty for postoperative pain as a VAS (visual analogue scale) score and requirement of rescue analgesia and results were compared with the placebo group. Pain scores (VAS score) was significantly lower in the pregabalin group as compared to the placebo group at 6, 12, 24, and at 48 h. Rescue analgesia requirements were also lower in the pregabalin group than the placebo group. Preemptive use of a single dose of oral 150 mg pregabalin reduces postoperative pain and rescue analgesic requirement in patients undergoing type 1 tympanoplasty.
Introduction Acute postoperative pain is often associated with impaired patient’s mobilization and functional rehabilitation [1]. Improper management of this pain may lead to a higher risk of complications, such as delayed wound healing, pulmonary embolism and even myocardial ischemia [2, 3]. Preemptive analgesia drugs are the medicines given before surgical incision as an antinociceptive treatment to improve patient’s satisfaction [4–6]. Several medicines have been tried for this purpose to reduce postoperative pain and analgesia requirement. Pregabalin and Gabapentin have emerged as effective premedication drugs to reduce postoperative pain [7–10]. Tympanoplasty type-1 is a commonly performed surgery by otologists for safe chronic suppurative otitis media (CSOM). It is usually performed via the postauricular approach and requires analgesics to decrease postoperative pain. This study aims to evaluate the use of a single dose of oral Pregabalin as preemptive analgesia in decreasing postoperative pain after postauricular type-1 tympanoplasty.
Keywords Type 1 tympanoplasty Preemptive analgesia Postoperative pain Pregabalin
Materials and Methods & Rajendra Kumar Teharia [email protected] 1
Department of Otorhinolaryngology, Pacific Institute of Medical Science, C-1402, Mangaldeep Apartment, near Pal Balaji Temple, Pal Road, Jodhpur, Rajasthan 342008, India
2
Department of Otorhinolaryngology, Pacific Institute of Medical Science, Udaipur, Rajasthan, India
This prospective experimental study was conducted in the department of otorhinolary
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