Vascular Ion Channels in Physiology and Disease
Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Io
- PDF / 16,067,892 Bytes
- 438 Pages / 439.42 x 683.15 pts Page_size
- 97 Downloads / 201 Views
cular Ion Channels in Physiology and Disease Foreword by Dr. Mark T. Nelson
Vascular Ion Channels in Physiology and Disease
Irena Levitan • Alex M. Dopico Editors
Vascular Ion Channels in Physiology and Disease Foreword by Mark T. Nelson
Editors Irena Levitan, PhD University of Illinois at Chicago Chicago, IL, USA
Alex M. Dopico, MD, PhD The University of Tennessee Memphis, TN, USA
ISBN 978-3-319-29633-3 ISBN 978-3-319-29635-7 DOI 10.1007/978-3-319-29635-7
(eBook)
Library of Congress Control Number: 2016940962 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Foreword
The central role of the vasculature in the function of the human body has been appreciated, at least in certain circles, since the time of ancient Greece, when the first known anatomical treatise that was not based on mysticism was produced. Early anatomists got much wrong, of course, crediting blood vessels with carrying tears and urine (but not sweat) in addition to blood, and suggesting the more fantastical role of conveying “breaths” of life and death (curiously these were said to be directed to right and left ears, respectively). Aristotle and his fourth century BC colleagues helped bring more empiricism to the subject, but their strictly anatomical approach based on animal dissections left much of vascular function to the imagination. Detailed studies of human cadavers, notably those performed by Leonardo da Vinci, the first to describe atherosclerosis, and later by Vesalius, considered by many to be the founder of modern human anatomy, dramatically advanced our understanding of the structure and basic responsibilities of the vascular system. However, medieval tools would prove to be no match for the twentieth century question of how various pieces and parts of the vascular system, though e
Data Loading...
