When rheumatoid arthritis is mentioned, should only dryness come to mind?
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ORIGINAL ARTICLE
When rheumatoid arthritis is mentioned, should only dryness come to mind? Ugur Gurlevik 1,2
&
Ahmet Karakoyun 1,2 & Erdogan Yasar 1,2
Received: 13 March 2020 / Revised: 9 April 2020 / Accepted: 21 April 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Objective To evaluate corneal parameters of rheumatoid arthritis (RA) patients by corneal topography. Methods One hundred two RA patients and 60 control subjects were enrolled. Corneal topography measurements and ophthalmologic findings were examined from all participants’ files. Results Corneal thickness measurements were significantly lower in the RA group (p = 0.025). All values of corneal curvatures (K1, K2, Kmean) in 3 mm, 5 mm, and 7 mm zones were found statistically significantly higher in the RA group compared with the control group. Forty-five RA patients had a dry eye. Disease duration was correlated with dry eye in the RA group. There was a significant correlation between the duration of disease in RA patients and mean corneal curvatures (p 0.012/0.010/0.007, 3/5/ 7 mm respectively) and central corneal thickness (p 0.025). There is no statistical difference between other topographic measurements. Conclusions The results suggest that RA patients have thinner and steeper corneas compared with control subjects. These parameters change in negative correlation as the duration of the disease increases. Key Points • Rheumatoid arthritis is an autoimmune disease with systemic involvement. • In rheumatoid arthritis, systemic involvement is affected in the eyes. • When it comes to eye involvement, it comes to mind that it makes the eyes more dryness. • In addition to dryness in the eyes, rheumatoid arthritis makes morphological changes in the cornea.
Keywords Cornea . Corneal curvature . Rheumatoid arthritis . Scheimpflug topography
Introduction Rheumatoid arthritis (RA) is an autoimmune, inflammatory disease with chronic and systemic involvement affecting mainly synovial joints. Intraocular involvement may be affected by the eye [1]. Women are 3 times more likely to have RA All persons named in the “Acknowledgments” section have provided me with written permission to be named. Our study has not been published anywhere before and the authors declare it. * Ugur Gurlevik [email protected] 1
Ophthalmology Department, Faculte of Medicine, Aksaray Education and Research Hospital, Aksaray University, Aksaray, Turkey
2
Physical Therapy and Rehabilitation Department, Faculte of Medicine, Aksaray Education and Research Hospital, Aksaray University, Aksaray, Turkey
than men [2]. The disease is mostly seen in the 4th–5th decades, but young people can be affected. Although the ocular involvement of the disease is more common as a dry eye, it can rarely be seen in anterior uveitis, retinal vasculitis, episcleritis, and scleritis [3]. Scleromalacia perforans and corneal melting RA are uncommon but severe eye posterior segment complications may require surgery [4, 5]. Although RA affects more eye anterior segment, som
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