QT Variability Index is Correlated with Autonomic Nerve Activity in Healthy Children
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ORIGINAL ARTICLE
QT Variability Index is Correlated with Autonomic Nerve Activity in Healthy Children Hirofumi Kusuki1 · Yuka Tsuchiya1 · Yuri Mizutani1 · Miki Nishio1 · Shota Oikawa2 · Rina Nagata2 · Yumi Kiriyanagi2 · Kayo Horio3 · Arisa Kojima4 · Hidetoshi Uchida4 · Namiko Kojima5 · Kazuyoshi Saito5 · Tsuneaki Sadanaga6 · Tadayoshi Hata1 Received: 4 March 2020 / Accepted: 12 June 2020 © The Author(s) 2020
Abstract The QT variability index (QTVI), which measures the instability of myocardial repolarization, is usually calculated from a single electrocardiogram (ECG) recording and can be easily applied in children. It is well known that frequency analysis of heart rate variability (HRV) can detect autonomic balance, but it is not clear whether QTVI is correlated with autonomic tone. Therefore, we evaluated the association between QTVI and HRV to elucidate whether QTVI is correlated with autonomic nerve activity. Apparently, healthy 320 children aged 0–7 years who visited Fujita Health University Hospital for heart checkup examinations were included. The RR and QT intervals of 60 continuous heart beats were measured, and the QTVI was calculated using the formula of Berger et al. Frequency analysis of HRV, including the QTVI analysis region, was conducted for 2 min and the ratio of low-frequency (LF) components to high-frequency (HF) components (LF/HF) and HF/(LF + HF) ratio was calculated as indicators of autonomic nerve activity. Then, the correlations between QTVI and these parameters were assessed. QTVI showed a significant positive correlation with LF/HF ratio (r = 0.45, p
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