Quantification of myocardial blood flow using 201 Tl SPECT and population-based input function
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ORIGINAL ARTICLE
Quantification of myocardial blood flow using and population-based input function Kazuhiro Koshino • Kazuhito Fukushima • Masaji Fukumoto Yuki Hori • Tetsuaki Moriguchi • Tsutomu Zeniya • Yoshihiro Nishimura • Keisuke Kiso • Hidehiro Iida
201
Tl SPECT
•
Received: 26 January 2014 / Accepted: 12 July 2014 / Published online: 22 July 2014 Ó The Japanese Society of Nuclear Medicine 2014
Abstract Objectives Thallium-201 (201Tl) single photon emission computed tomography (SPECT) is an important tool in the diagnosis of ischemic heart disease. Absolute quantification of myocardial blood flow (MBF) has the potential to provide more useful information on myocardial perfusion than semi-quantitative assessments. This study aimed to validate the quantification of MBF using 201Tl cardiac SPECT based on a population-averaged input function (STD-IF) and one-point blood sample technique. Methods 201Tl emission and computed tomography (CT)based attenuation scans were performed on 11 healthy volunteers at rest using a SPECT/CT scanner. Individual input functions (IND-IFs) during the emission scans were based on arterial blood samples. The STD-IF technique was validated as follows: (1) optimal time to calibrate a STD-IF was determined to minimize differences between the calibrated STD-IF and the IND-IFs. (2) Tissue timeactivity curves (TTACs) were generated based on a singletissue compartment model for MBFtrue = 0.5, 1.0, 1.5, and 2.0 mL/min/g, a constant distribution volume of 45 mL/
K. Koshino (&) Y. Hori T. Moriguchi T. Zeniya H. Iida Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan e-mail: [email protected] K. Fukushima Y. Nishimura K. Kiso The Department of Radiology, National Cerebral and Cardiovascular Center Hospital, 5-7-1 Fujishirodai, Suita, Osaka, Japan M. Fukumoto Department of Radiology, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka-shi, Osaka, Japan
mL, and IND-IFs. The pseudo STD-IF for each subject was generated using the leave-one-out technique. Using the optimal calibration time and the pseudo STD-IFs, MBF values were estimated on the TTACs with an autoradiography method. Optimal mid-scan time (MST) with a fixed duration of 20 min was determined to minimize intersubject variation in estimated MBF errors, and (3) Global and regional MBF values estimated with pseudo STD-IFs were compared to those with IND-IFs using the optimal calibration time and MST. Results The optimal calibration time and MST were both 20 min after 201Tl injection. Global MBF determined using both IND-IFs and pseudo STD-IF showed significant correlations with rate-pressure products, R2 = 0.645; p \ 0.01 and R2 = 0.303; p \ 0.05, respectively. The mean percent error in regional MBF using pseudo STD-IFs was 0.69 ± 7.80 % (-12.80 to 14.25 %). No significant difference was observed between regional MBF values using IND-IFs and pseudo STD-IFs. Conclusion This study demonstr
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