Radiation-induced lymphopenia: the main aspects to consider in immunotherapy trials for endometrial and cervical cancer
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RESEARCH ARTICLE
Radiation‑induced lymphopenia: the main aspects to consider in immunotherapy trials for endometrial and cervical cancer patients K. Holub1,2 · A. Vargas2,3 · A. Biete2 Received: 14 February 2020 / Accepted: 19 March 2020 © Federación de Sociedades Españolas de Oncología (FESEO) 2020
Abstract Background Although the chemotherapy-induced depletion of circulating white blood cells (WBC) is well recognized, the impact of exclusive radiotherapy (RT) on the different subpopulations of WBC remains unexplored. This may be important for immunotherapy administrated in combination with radiation, especially in malignant tumors usually treated with RT or chemoradiotherapy (CRT), and characterized by a high mutational burden, such as endometrial (EC) or cervical cancer (CC). We aimed to evaluate the impact of RT and CRT on circulating WBC in uterine cancers and its correlation with survival. Material and methods A total of 202 consecutive patients with uterine cancers treated with RT or CRT between 2009 and 2016 in a large European center and with available basal and post-treatment blood tests were retrospectively evaluated. EC and CC patients were analyzed separately. The differences between pre- and post- treatment WBC mean values were evaluated independently in patients treated with CRT and exclusive RT. Two-sided T test for paired samples and Kaplan–Meier curves were applied for analysis (p value
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