Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review
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REVIEW
Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review Andre´s Coca-Pelaz
. Antti A. Ma¨kitie
. Primozˇ Strojan .
June Corry . Avraham Eisbruch . Jonathan J. Beitler . Sandra Nuyts . Robert Smee . Johannes A. Langendijk . William M. Mendenhall . Cesare Piazza . Alessandra Rinaldo
. Alfio Ferlito
Received: October 6, 2020 / Accepted: October 28, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: As a result of the increased use of radiotherapy (RT) and improved long-term overall survival of patients with cancers of the head and neck (HN), the frequency of radiationinduced sarcomas of the head and neck (RISHN) may be increasing. The main objective of this systematic review was to determine the existing
This article was written by members of the International Head and Neck Scientific Group (www.IHNSG.com). A. Coca-Pelaz (&) Department of Otolaryngology, Hospital Universitario Central de Asturias-University of Oviedo, Instituto de Investigacio´n Sanitaria del Principado de Asturias, IUOPA, CIBERONC, Oviedo, Asturias, Spain e-mail: [email protected] A. A. Ma¨kitie Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland P. Strojan Department of Radiation Oncology, Institute of Oncology, University of Ljubljana, Ljubljana, Slovenia J. Corry Division Radiation Oncology, Department of Medicine, St. Vincent’s Hospital/The University of Melbourne, Melbourne, VIC, Australia
evidence on the frequency, treatment, and outcome of RISHN. Methods: Using PRISMA guidelines we conducted a systematic review of the literature published from 2000 to 2020. Results: Our review includes data of 560 patients from 64 articles. The total frequency of RISHNs among the reviewed series was 0.15%. The most frequent location of the primary tumor treated by RT was the nasopharynx. The mean RT dose used was 62 Gy, mean latency interval between irradiation and occurrence of RISHN was 11.1 years, and the most common RISHN location was the sinonasal region. A. Eisbruch Department of Radiation Oncology, University of MI Hospitals–Michigan Medicine, Ann Arbor, MI, USA J. J. Beitler Departments of Radiation Oncology, Otolaryngology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA S. Nuyts Department of Oncology, Radiation-Oncology, KU Leuven, University of Leuven, University Hospitals Leuven, Leuven, Belgium R. Smee Department of Radiation Oncology, The Prince of Wales Cancer Centre, Sydney, NSW, Australia J. A. Langendijk Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Adv Ther
Osteosarcoma was the principal histology, followed by fibrosarcoma. Surgery was the most frequently applied treatment modality. Of all patients with RISHN, 40.7% died of this disease after a mean interval of 13.9 months. Conclusions: Notwithstanding the increased use of RT, the number of reported RISHNs has not increased substantially during the past two decades. Surgery wit
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