Recent advances in the synthetic approaches to 2-pyridones (microreview)
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Dedicated to Academician of the Russian Academy of Sciences Oleg N. Chupakhin on the occasion of his birthday
Recent advances in the synthetic approaches to 2-pyridones (microreview) Dhananjay Bhattacherjee1*, Grigory V. Zyryanov1,2, Pralay Das3,4 1
Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia; е-mail: [email protected] 2 Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg 620108, Russia 3 Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India 4 Academy of Scientific and Innovative Research, Submitted June 9, 2020 Accepted after revision July 27, 2020
Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(9), 1152–1154
This microreview focuses on the methodologies for the synthesis of 2-pyridones and their biological applications. Various types of synthetic methods reported in the last 6 years (starting from the year 2014 and onward) have been discussed. Functionalization reactions of 2-pyridones have not been taken into account. Introduction Heterocyclic compounds constitute an important backbone of modern pharmaceutical and medicinal chemistry and play a pivotal role in the growth as well as metabolism of a living cell. Among them, functionalized 2-pyridone scaffolds1 have attracted considerable attention because of the broad spectrum of their biological activity, such as anxiolytic,2a antimicrobial,2b antituberculosis,2c antiviral,2d anticancer,2e and anti-inflammatory.2f Prompted by inherent biological Dhananjay Bhattacherjee has earned his PhD at the Institute of Himalayan Bioresource Technology, India, and presently he is a postdoctoral senior research fellow in Professor G. V. Zyryanov research group. His research mainly focuses on synthetic organic chemistry, hypervalent iodine chemistry, green chemistry, and chemosensors. Grigory V. Zyryanov, Professor of the RAS, earned his PhD (Organic Chemistry) in 2000, and Dr. Sc. (Organic Chemistry) in 2012 from the Ural Federal University. His current research interests include the development of novel approaches and PASE-methods in synthetic organic chemistry, green chemistry, coordination chemistry, chemistry of materials, photochemistry, chemosensors.
importance of 2-pyridones and diverse commercial applications, a plethora of methodologies has been investigated for the synthesis of 2-pyridones.3 2-Pyridones can be accessed through variety of transformations such as cyclization, cycloaddition, metal-catalyzed annulation, and ring rearrangement reactions.4 In this microreview, we have focused on the recent developments (starting from the year 2014 and onward) in the synthesis of 2-pyridones. Multicomponent synthesis of 2-pyridones Multicomponent reactions (MCRs) are powerful synthetic tools for the convergent synthesis of drug-like polyfunctional compounds in a one-pot, one-ste
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