Red maca ( Lepidium meyenii ) reduced prostate size in rats
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BioMed Central
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Red maca (Lepidium meyenii) reduced prostate size in rats Gustavo F Gonzales*1,4, Sara Miranda1, Jessica Nieto1, Gilma Fernández2, Sandra Yucra1, Julio Rubio1,4, Pedro Yi3,4 and Manuel Gasco1,4 Address: 1Department of Biological and Physiological Sciences. Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru, 2Departament of Chemistry. Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru, 3Faculty of Veterinary Medicine and Animal Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru and 4Instituto de Investigaciones de la Altura. Universidad Peruana Cayetano Heredia, Lima, Peru Email: Gustavo F Gonzales* - [email protected]; Sara Miranda - [email protected]; Jessica Nieto - [email protected]; Gilma Fernández - [email protected]; Sandra Yucra - [email protected]; Julio Rubio - [email protected]; Pedro Yi - [email protected]; Manuel Gasco - [email protected] * Corresponding author
Published: 20 January 2005 Reproductive Biology and Endocrinology 2005, 3:5
doi:10.1186/1477-7827-3-5
Received: 25 October 2004 Accepted: 20 January 2005
This article is available from: http://www.rbej.com/content/3/1/5 © 2005 Gonzales et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Epidemiological studies have found that consumption of cruciferous vegetables is associated with a reduced risk of prostate cancer. This effect seems to be due to aromatic glucosinolate content. Glucosinolates are known for have both antiproliferative and proapoptotic actions. Maca is a cruciferous cultivated in the highlands of Peru. The absolute content of glucosinolates in Maca hypocotyls is relatively higher than that reported in other cruciferous crops. Therefore, Maca may have proapoptotic and anti-proliferative effects in the prostate. Methods: Male rats treated with or without aqueous extracts of three ecotypes of Maca (Yellow, Black and Red) were analyzed to determine the effect on ventral prostate weight, epithelial height and duct luminal area. Effects on serum testosterone (T) and estradiol (E2) levels were also assessed. Besides, the effect of Red Maca on prostate was analyzed in rats treated with testosterone enanthate (TE). Results: Red Maca but neither Yellow nor Black Maca reduced significantly ventral prostate size in rats. Serum T or E2 levels were not affected by any of the ecotypes of Maca assessed. Red Maca also prevented the prostate weight increase induced by TE treatment. Red Maca administered for 42 days reduced ventral prostatic epithelial height. TE increased ventral prostatic epithelial height and duct luminal area. These increases by TE were reduced after treatment with Red Maca for 42 days. Histology pictures in rats treated with
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