Silver nanoparticles-induced nephrotoxicity in rats: the protective role of red beetroot ( Beta vulgaris ) juice
- PDF / 1,530,582 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 24 Downloads / 188 Views
RESEARCH ARTICLE
Silver nanoparticles-induced nephrotoxicity in rats: the protective role of red beetroot (Beta vulgaris) juice Tarfa Albrahim 1 Received: 21 February 2020 / Accepted: 9 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The present study was designed to investigate the nephrotoxicity of silver nanoparticles (AgNPs; 80 mg/kg; > 100 nm) and to evaluate the protective effect exercised by Beta vulgaris (beetroot) juice (RBR; 200 mg/kg) on male rats’ kidney. Serum-specific parameters (urea, creatinine, electrolytes and histopathology of kidney tissue) were examined to assess the AgNPs nephrotoxicity effect. Moreover, this study analysed oxidative stress (lipid peroxidation, glutathione, superoxide dismutase and catalase) and anti-apoptotic markers (Bcl-2). AgNPs intoxication increased kidney function marker levels and lipid peroxidation and decreased the glutathione, superoxide dismutase and catalase activities in kidney tissue. Additionally, Bcl-2 expression was downregulated following AgNPs intoxication. Moreover, AgNPs induced a significant increase in renal DNA damage displayed as an elevation in tail length, tail DNA percentage and tail moment. Interestingly, RBR post-treatment restored the biochemical and histological alterations induced by AgNPs exposure, reflecting its nephroprotective effect. Collectively, the present data suggest that RBR could be used as a potential therapeutic intervention to prevent AgNPs-induced nephrotoxicity. Keywords Silver nanoparticles . Red beetroot . Oxidative stress . Bcl-2 expression . Kidney toxicity
Introduction Silver nanoparticles (AgNPs) are present in many consumable products such as topical antibacterial formulations, hygiene sprays, food additives, baby products and kitchen utensils (Alajmi et al. 2019; Bao et al. 2020). However, to date, AgNPs full toxicity profile has not been fully clarified. It has been recommended that in vivo and in vitro nanotoxicological studies should be carried out in order to understand it (Lekamge et al. 2018; Tortella et al. 2020). Due to the small sizes of nanoparticles, they penetrate easily the membrane barriers (ElBorady et al. 2020). In this regard, AgNPs can enter the living organism easily through the dermal, inhalation and oral routes. Responsible editor: Mohamed M. Abdel-Daim Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11356-020-09671-7) contains supplementary material, which is available to authorized users. * Tarfa Albrahim [email protected] 1
College of Health and Rehabilitation Sciences, Department of Health Sciences, Clinical Nutrition, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
After that, circulation facilitates Ag accumulation in various tissues and organs such as the spleen, liver, kidney and brain. Inside the cells, Ag can induce failure and dysfunction of vital macromolecule structures such as DNA, RNA and proteins (Abramenko et al. 2018; Fukushima et al. 2020). Some reports suggest that AgNPs tox
Data Loading...
