Regulatory Mechanism of Rosemary Extract ( Rosmarinus officinalis ) on Human Skin Fibroblasts During Ultraviolet A Photo
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RESEARCH PAPER
Regulatory Mechanism of Rosemary Extract (Rosmarinus officinalis) on Human Skin Fibroblasts During Ultraviolet A Photoaging Feng Mao1 • Zhongxiao Wu1 • Yanna Shen1 • Yougang Ren1 • Mouzhe Yang1 • Xiaoli Li1 Li Zhang1
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Received: 18 March 2020 / Accepted: 6 November 2020 Ó Shiraz University 2020
Abstract In this study, human skin fibroblasts human dermis fibroblasts were used as the object, the possible effects and mechanisms of rosemary extract on repeated exposure to Ultraviolet A (UVA) induced senescence of human skin fibroblasts were investigated. During the research, we mainly carried out through two parts. The first part mainly explores the effect of repeated UVA radiation on human skin fibroblasts; the second part mainly discusses the effect of rosemary extract on the induction of human skin formation by repeated UVA radiation. The results showed that repeated UVA irradiation of human skin fibroblasts can induce aging phenomena, such as slow proliferation and an increase in b-galactosidase staining positive rate; repeated exposure of rosemary extract to low-dose UVA can slow down human skin fibroblasts to age. Its mechanism may be related to reducing the total intracellular ROS, the mRNA expression of MMP-1 and MMP-3, and the expression of p53 protein. In short, this study provides a new approach and theoretical basis for the development and application of natural sunscreens. Keywords Rosemary extract Human skin fibroblasts UVA photoaging ROS p53 Protein
1 Introduction Skin aging includes natural aging and photoaging. Photoaging refers to the long-term repeated exposure to ultraviolet radiation on the skin of exposed areas based on & Li Zhang [email protected] Feng Mao [email protected] Zhongxiao Wu [email protected] Yanna Shen [email protected] Yougang Ren [email protected] Mouzhe Yang [email protected] Xiaoli Li [email protected] 1
Department of Dermatology, Ningbo No. 6 Hospital, Ningbo 315040, China
natural aging, which triggers accelerated skin aging and the process of natural aging (Krutmann et al. 2017). Therefore, it is necessary to urgently deepen the understanding of the etiology and pathogenesis of photoaging skin diseases and further guide patients to effectively prevent and treat skin photoaging in daily life, which is a clinical problem that needs to be solved. There are many mechanisms that cause photoaging, which are interrelated and complex, mainly including oxidative stress, DNA damage, apoptosis, the role of matrix metalloproteinases, inflammatory reactions, and the role of advanced immunosuppression advanced glycation end products (Rodopoulou et al. 2018). UVA radiation can induce tissue cells to produce reactive oxygen species (ROS). Accumulation of a large amount of ROS will damage skin tissues, causing collagen and elastic fibers in the dermis to lose their normal structure, break, and even degenerate (Glazer et al. 2017; Rothhammer and Quintana 2019; Pappas et al. 2016). ROS can promote matrix metall
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