Relationship between autoantibodies combination, metabolic syndrome components and diabetic complications in autoimmune
- PDF / 267,994 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 34 Downloads / 164 Views
ORIGINAL ARTICLE
Relationship between autoantibodies combination, metabolic syndrome components and diabetic complications in autoimmune diabetes in adults Kristina Blaslov • Tomislav Bulum • ´ uc´a • Lea Duvnjak Jadranka Knezˇevic´-C
Received: 3 March 2014 / Accepted: 5 June 2014 Ó Springer Science+Business Media New York 2014
Abstract The aim of our study was to establish the possible association between double or triple antibody positivity and latent autoimmune diabetes (LADA) phenotype in the context of metabolic syndrome (MS) prevalence and its individual components. This cross-sectional study population comprised 69 islet cell antibody-positive patients coming for their comprehensive annual review. They were divided into three groups according to antibody positivity. Twenty-five (36.2 %) were male, mean age of 51 years with disease duration of 8 years. Twenty-eight (40.58 %) were positive only for GAD Abs, 26 (37.68 %) were positive for ICA and GAD Abs and 15 (21.74 %) were positive for GAD, ICA, and IA2 Abs. The lowest value of waist circumference, MS, and artherial hypertension prevalence was found in the group positive for all three antibodies. In the multinomial multivariate logistic regression model, MS was negatively associated with triple Abs positivity compared to single Ab positivity and double Abs positivity. Our results highlight the importance of inverse association between simultaneous Abs positivity for ICA, GAD, and IA2 with the MS and its components present in LADA patients. This inverse relationship might implicate that LADA patients are phenotypically closer to T1DM. The contribution of IA2 Ab positivity merits is to be considered in the determination of LADA phenotypes, while its diagnostic value needs to be clarified in future follow-up studies.
K. Blaslov (&) T. Bulum J. Knezˇevic´-C´uc´a L. Duvnjak Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia e-mail: [email protected]
Keywords Adult onset diabetes mellitus Autoimmunity Metabolic syndrome
Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by destruction of pancreatic islet b cell and the consequent insulin deficiency mediated by autoreactive T cells [1]. Circulating autoantibodies to islet cell cytoplasmic antigens (ICA Abs), glutamic acid decarboxylase enzyme (GAD Abs), and tyrosine phosphatase-like transmembrane glycoprotein (IA2 Abs) are the most common serum markers of T1DM [2–5]. Even though T1DM is usually diagnosed in childhood, adolescence, and young adulthood, it can develop at any age since the disease onset depends on different genetic and environmental factors [6]. According to recent World Health Organization and American Diabetes Association classification, there is also a subgroup of patients with disease onset in later adulthood named latent autoimmune diabetes in adults (LADA) or slowly progressive T1DM [7, 8]. LADA is characterized by clinical presentation
Data Loading...
