Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis
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META- ANALYSIS
Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis S. D’Andrea1 A. Martorella1 F. Coccia1 C. Castellini1 E. Minaldi1 M. Totaro1 A. Parisi1 F. Francavilla1 S. Francavilla1 A. Barbonetti 1 ●
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Received: 24 May 2020 / Accepted: 26 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Despite a biological plausibility of a direct link between low vitamin D and androgen deficiency, the association remains inconclusive in epidemiological studies. Therefore, this systematic review and meta-analysis of case-control studies aim to assess whether and in what populations such an association can be demonstrated. Methods A systematic search was performed in PubMed, EMBASE, Cochrane Library, Web of science, Science Direct, and CINAHL. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) in total testosterone (TT) levels between men with 25-hydroxyvitamin D (25(OH)D)
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