Research in Computational Molecular Biology 14th Annual Internat

This volume contains the papers presented at RECOMB 2010: the 14th Annual International Conference on Research in Computational Molecular Biology held in Lisbon, Portugal, during April 25–28, 2010. The RECOMB conference series was started in 1997 by Sorin

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Bonnie Berger (Ed.)

Research in Computational Molecular Biology 14th Annual International Conference, RECOMB 2010 Lisbon, Portugal, April 25-28, 2010 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editor Bonnie Berger Massachusetts Institute of Technology Mathematics Department Computer Science and Artificial Intelligence Laboratory 77 Massachusetts Avenue, Cambridge, MA 02139, USA E-mail: [email protected]

Library of Congress Control Number: 2010924885

CR Subject Classification (1998): J.3, H.2.8, I.2, F.2.2, I.6, F.2 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-642-12682-0 Springer Berlin Heidelberg New York 978-3-642-12682-6 Springer Berlin Heidelberg New York

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Preface

This volume contains the papers presented at RECOMB 2010: the 14th Annual International Conference on Research in Computational Molecular Biology held in Lisbon, Portugal, during April 25–28, 2010. The RECOMB conference series was started in 1997 by Sorin Istrail, Pavel Pevzner, and Michael Waterman. RECOMB 2010 was hosted by INESC-ID and Instituto Superior Tecnico, organized by a committee chaired by Arlindo Oliveira and took place at the International Fair of Lisbon Meeting Centre. This year, 36 papers were accepted for presentation out of 176 submissions. The papers presented were selected by the Program Committee (PC) assisted by a number of external reviewers. Each paper was reviewed by three members of the PC, or by external reviewers, and there was an extensive Web-based discussion over a period of two weeks, leading to the final decisions. RECOMB 2010 also introduced a Highlights Track, in which six additional presentations by senior authors were chosen from papers published in 2009. The RECOMB conference series is closely associated with the Journal of Computational Biology, which traditionally publishes spe