Research in Computational Molecular Biology 17th Annual Internat

This book constitutes the refereed proceedings of the 17th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2013, held in Beijing, China, in April 2013. The 32 revised full papers were carefully reviewed and selected

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Minghua Deng Rui Jiang Fengzhu Sun Xuegong Zhang (Eds.)

Research in Computational Molecular Biology 17th Annual International Conference, RECOMB 2013 Beijing, China, April 2013 Proceedings

123

Lecture Notes in Bioinformatics

7821

Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Minghua Deng Rui Jiang Fengzhu Sun Xuegong Zhang (Eds.)

Research in Computational Molecular Biology 17th Annual International Conference, RECOMB 2013 Beijing, China, April 7-10, 2013 Proceedings

13

Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Minghua Deng Peking University, Beijing, China E-mail: [email protected] Rui Jiang Tsinghua University, Beijing, China E-mail: [email protected] Fengzhu Sun University of Southern California Los Angeles, CA, USA E-mail: [email protected] Xuegong Zhang Tsinghua University, Beijing, China E-mail: [email protected]

ISSN 0302-9743 e-ISSN 1611-3349 ISBN 978-3-642-37194-3 e-ISBN 978-3-642-37195-0 DOI 10.1007/978-3-642-37195-0 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2013933233 CR Subject Classification (1998): J.3, H.2.8, G.3, F.2.2, I.5.2, I.6.3-5 LNCS Sublibrary: SL 8 – Bioinformatics

© Springer-Verlag Berlin Heidelberg 2013 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in ist current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

The RECOMB conference series — with its full name the Annual International Conference on Research in Computational Molecular Biology — was started in 1997 by Sorin Istrail, Pavel Pevzner, and Michael Waterman. The 17th Annual International Conference on Research in Computational Molecular Biology or RECOMB 2013 was held at Tsinghua University, Beijing, China, hosted by the Bioinformatics Division of Tsinghua National