Research in Computational Molecular Biology 15th Annual Internat

This book constitutes the refereed proceedings of the 15th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2011, held in Vancouver, Canada, in March 2011. The 43 revised full papers were carefully reviewed and select

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Vineet Bafna S. Cenk Sahinalp (Eds.)

Research in Computational Molecular Biology 15th Annual International Conference, RECOMB 2011 Vancouver, BC, Canada, March 28-31, 2011 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Vineet Bafna University of California San Diego EBU3b, #4218 9500 Gilman Drive La Jolla, CA 92093-0404, USA E-mail: [email protected] S. Cenk Sahinalp Simon Fraser University School of Computing Science 8888 University Drive Burnaby, BC, V5A 1S6, Canada E-mail: [email protected]

ISSN 0302-9743 e-ISSN 1611-3349 e-ISBN 978-3-642-20036-6 ISBN 978-3-642-20035-9 DOI 10.1007/978-3-642-20036-6 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011923333 CR Subject Classification (1998): J.3, H.2.8, I.2, F.2.2, I.6, F.2 LNCS Sublibrary: SL 8 – Bioinformatics

© Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

This volume contains the papers presented at RECOMB 2011: the 15th Annual International Conference on Research in Computational Molecular Biology held in Vancouver, Canada, during March 28–31, 2011. The RECOMB conference series was started in 1997 by Sorin Istrail, Pavel Pevzner, and Michael Waterman. RECOMB 2011 was hosted by the Lab for Computational Biology, Simon Fraser University, and took place at the Fairmont Hotel Vancouver. This year, 43 papers were accepted for presentation out of 153 submissions. The papers presented were selected by the Program Committee (PC) assisted by a number of external reviewers. Each paper was reviewed by at least three members of the PC, or by external reviewers, and there wa