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Paul C. Guest Editor

Reviews on Biomarker Studies of Metabolic and MetabolismRelated Disorders

Advances in Experimental Medicine and Biology Proteomics, Metabolomics, Interactomics and Systems Biology Series Editor Daniel Martins-de-Souza University of Campinas (UNICAMP) Institute of Biology Laboratory of Neuroproteomics Campinas, Brazil

This series of volumes focuses on concepts, techniques and recent advances in the field of proteomics, interactomics, metabolomics and systems biology. Recent advances in various ‘omics’ technologies enable quantitative monitoring of myriad various biological molecules in a high-throughput manner, and allow determination of their variation between different biological states on a genomic scale. Now that the sequencing of various genomes, from prokaryotes to humans, has provided the list and linear sequence of proteins and RNA that build living organisms, defining the complete set of interactions that sustain life constitutes one of the key challenges of the postgenomic era. This series is intended to cover experimental approaches for defining protein-protein, protein-RNA, protein-DNA and protein-lipid interactions; as well as theoretical approaches dealing with data analysis, integration and modeling and ethical issues. More information about this series at http://www.springer.com/series/15040

Paul C. Guest Editor

Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders

Editor Paul C. Guest Department of Biochemistry and Tissue Biology Institute of Biology University of Campinas (UNICAMP) Campinas, Brazil

ISSN 0065-2598     ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-12667-4    ISBN 978-3-030-12668-1 (eBook) https://doi.org/10.1007/978-3-030-12668-1 Library of Congress Control Number: 2019935517 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and