Measles mumps and rubella virus vaccine
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Encephalitis: case report A 6-year-old boy developed encephalitis following vaccination with measles mumps and rubella virus vaccine. The boy was hospitalised with a complaints of dizziness. He reported experiencing increased body temperature after the sixth dose of booster vaccination against measles, mumps and rubella with measles mumps and rubella virus vaccine [dosage and route not stated]. The following day, he developed vesicular rash, and was diagnosed with chickenpox. He received treatment with aciclovir therapy. The new elements of rash appeared within the next three days, followed by normalisation of the body temperature. He tried to get out of the bed on day 14 of the post-vaccination period (day 8 of the illness); however, he fell and complained of dizziness during the day. The complaints continued, and he was admitted the following day (current admission). On admission, he was in a severe condition and was febrile. He was unstable in the Romberg position. Examination revealed coarse nystagmus in extreme, finger to nose test with intention with static and dynamic ataxia. His skin was clean and pale pink. Scabs without signs of secondary infection were noted on the skin of the trunk and limbs. The mucous membranes of the oral cavity were clean and moist without swelling. His heart sounds were sonorous with HR of 98 beats/minute. Chickenpox and encephalitis were suspected. On day 16 of the postvaccination period, lumbar puncture was performed, which showed cytosis 6/3, protein 0.272%, neutrophils 4, mononuclear cells 2 and glucose 2.6 mmol/L. A diagnosis of encephalitis was confirmed. The boy was treated with aciclovir with pathogenetic and symptomatic therapy. A slow positive dynamics, wave-like course of the disease, increased ataxia after a relative regression of neurological symptoms was noted. Interferonα-2b [Viferon] and unspecified neurometabolic drugs were added to the therapy. He was diagnosed with chickenpox complicated by encephalitis (severe and cerebellar form), and was discharged on day 23 of hospitalisation. Virological examination of the blood revealed herpes zoster confirming the clinical diagnosis. Author comment: The presented observation indicates that at the height of the vaccination period, the child had an intercurrent disease - chickenpox, complicated by the development of encephalitis. According to the timing of the onset of symptoms of encephalitis, it could be attributed to [measles mumps and rubella virus vaccine]. Friedman IV, et al. A case of varicella zoster, complicated by encephalitis in the post-vaccination period in a child revaccinated against measles, rubella and parotitis - how to evaluate it correctly? Pediatriya 98: 136-139, No. 1, Feb 2019. Available from: URL: http://doi.org/10.24110/0031-403X-2019-98-1-136-139 803438438 [Russian; sumamrised from a translation] - Russia
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Reactions 7 Dec 2019 No. 1782
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