Measles, mumps and rubella virus vaccine
- PDF / 141,918 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 93 Downloads / 202 Views
1
S
Orchitis: 3 case reports Three otherwise healthy patients (2 adults and 1 infant) developed orchitis after immunisation with a measles, mumps and rubella (MMR) virus vaccine [Priorix; dosage not stated]. A 37-year-old man felt unwell immediately after receiving the MMR vaccine and developed bilateral testicular discomfort and swelling 3 days later. Tender inguinal lymphadenopathy and bilateral submandibular gland swelling were observed, and inflammatory orchitis was confirmed by ultrasonography. No evidence of torsion or infectious epididymo-orchitis was detected. The swelling was treated conservatively and persisted for 5 weeks before resolving spontaneously, without ongoing sequelae. A 36-year-old man experienced a high fever, pharyngitis and cervical lymphadenopathy 48 hours after receiving a second dose of the MMR vaccine; the first dose was administered in 1991. He developed unilateral testicular discomfort and swelling the following day. Ultrasound detected nonspecific inflammatory orchitis, with no evidence of torsion or infectious epididymo-orchitis. His orchitis resolved after 7 days with conservative treatment. No ongoing sequelae was observed. A 12-month-old boy developed unilateral scrotal and testicular swelling 2 weeks after his first MMR vaccination. The swelling resolved over several days, however he presented 6 weeks after vaccination with bruising and mucosal bleeding. Chronic idiopathic thrombocytopenia was detected, which persisted for approximately 4 months before resolving spontaneously. Author comment: "Clearly it is not possible to establish causality, as defined by the Bradford Hill criteria, on the basis of two unusual cases of post-MMR vaccine orchitis . . . Nevertheless, an immune-mediated phenomenon is a biologically plausible explanation for the development of orchitis following MMR vaccination." Clifford V, et al. Mumps vaccine associated orchitis: Evidence supporting a potential immune-mediated mechanism. Vaccine 28: 2671-2673, No. 14, 19 Mar 2010. Available from: URL: http://dx.doi.org/10.1016/j.vaccine.2010.01.007 803013680 Australia
0114-9954/10/1302-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 22 May 2010 No. 1302
Data Loading...
