Rubidium-82 generator yield and efficiency for PET perfusion imaging: Comparison of two clinical systems
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Division of Cardiology, University of Ottawa Heart Institute, National Cardiac PET Centre, Ottawa, ON, Canada Division of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada Cardiac Imaging Nuclear Associates, Los Angeles, CA
Received Feb 13, 2020; accepted Apr 18, 2020 doi:10.1007/s12350-020-02200-6
Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared. Methods. N 5 515 sequential daily quality assurance (QA) reports from 9 CardioGen-82Ò and 9 RUBY-FILLÒ generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILLÒ system to determine an empirical correction-factor used to convert CardioGen-82Ò daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mLmin21) to RUBY-FILLÒ equivalent values (integrated ‘total’ of 35 mL elution at 20 mLmin21). The generator yield (82Rb) and production efficiency (82Rb yield/82Sr parent activity) were measured and compared after this conversion to a common scale. Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82Ò vs RUBY-FILLÒ (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, P < 0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82Ò) values were found to under-estimate the integrated ‘total’ (RUBY-FILLÒ) activity by * 24% at 50 mLmin21. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82Ò efficiency remained slightly lower than the RUBY-FILLÒ system on average (88 ± 4% vs 95 ± 4%, P < 0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use. Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGenÒ 82 vs RUBY-FILLÒ daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82Ò system was * 7% lower than RUBY-FILLÒ over the full period of clinical use. (J Nucl Cardiol 2020) Key Words: Myocardial perfusion imaging Æ positron emission tomography Æ rubidium-82 generator Æ daily quality assurance Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12350-020-02200-6) contains supplementary material, which is available to authorized users. The authors of this article have provided a PowerPointfile, available for download at SpringerLink, which summarises thecontents of the paper and is free for re-use at meetings andpresentations. Search for the article DOI on SpringerLink.com.
Reprint requests: Robert A. deKemp, PhD, Division of Cardiology, University of Ottawa Heart Institute, National Cardiac PET Centre, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada; [email protected] 1071-
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