Selenium Its Molecular Biology and Role in Human Health
The selenium field has grown dramatically in the years since the first edition of Selenium: Its Molecular Biology and Role in Human Health was published in 2001. All aspects of selenium biology have advanced with many new approaches and insights into the
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Dolph L. Hatfield Marla J. Berry Vadim N. Gladyshev ●
Editors
Selenium Its Molecular Biology and Role in Human Health Third Edition
Editors Dolph L. Hatfield Molecular Biology of Selenium Section Laboratory of Cancer Prevention Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, MD 20892, USA [email protected]
Marla J. Berry Department of Cell and Molecular Biology John A. Burns School of Medicine University of Hawaii Honolulu, HI 96813, USA [email protected]
Vadim N. Gladyshev Division of Genetics, Department of Medicine Brigham and Women’s Hospital Harvard Medical School Boston, MA 02115, USA [email protected]
ISBN 978-1-4614-1024-9 e-ISBN 978-1-4614-1025-6 DOI 10.1007/978-1-4614-1025-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011939788 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Dedication
This book is dedicated to Drs. August Böck and Thressa Stadtman. These outstanding scientists have had a major impact on the selenium field and are responsible for key discoveries in the biochemistry and molecular biology of this fascinating element. Dr. Böck’s research provided the foundation of how selenium makes its way into selenoproteins as selenocysteine, the 21st amino acid in the genetic code, in eubacteria. In his first work in the field, he identified unique requirements for selenocysteine incorporation into protein [1]. His second publication in this area was a highly significant collaboration with Dr. Stadtman showing that the in-frame TGA codon in the formate dehydrogenase gene corresponded to selenocysteine in the protein [2]. Dr. Böck then turned his attention to solving the question how selenium was incorporated into protein, discovering genes required for the pathway, characterizing their function, and ultimately establishing the mechanism for selenocysteine biosynthesis and insertion in bacteria (see reviews and Dr. Böck’s and his group’s many landmark discoveries in [3–5]). All subsequent research, including that in eukaryotes and archaea, benefited from these pioneering efforts. Dr. Böck followed these major discoveries with many elegant, highly important findings that
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