Sensing Environmental Factors: The Emerging Role of Receptors in Epidermal Homeostasis and Whole-Body Health
Epidermal keratinocytes have been recognized to form the water-impermeable structure and this barrier function is critical, especially for terrestrial animals. However, recent findings have dramatically changed the picture of epidermal keratinocytes, plac
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Skin Stress Response Pathways Environmental Factors and Molecular Opportunities
Skin Stress Response Pathways
Georg T. Wondrak Editor
Skin Stress Response Pathways Environmental Factors and Molecular Opportunities
123
Editor Georg T. Wondrak Department of Pharmacology and Toxicology College of Pharmacy & The University of Arizona Cancer Center University of Arizona Tucson, AZ USA
ISBN 978-3-319-43155-0 DOI 10.1007/978-3-319-43157-4
ISBN 978-3-319-43157-4
(eBook)
Library of Congress Control Number: 2016946320 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
If the skin were parchment and the blows you gave were ink, Your own handwriting would tell you what I think. (William Shakespeare, The Comedy of Errors)
It is now understood that the interplay between environmental exposure and cellular stress response pathways plays a critical role in skin structure and function, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open novel avenues for targeted therapeutic strategies that may benefit skin health of patients in the near future. The comprehensive coverage of cutaneous cell stress response pathways as presented for the first time in this book is intended to provide a state-of-the-art perspective that is of interest to both basic researchers focusing on fundamental skin biology in the context of environmental exposure as well as translational biomedical health care professionals. With the completion of this project, I would like to express my gratitude to those who were instrumental in its creation. First and foremost, I would like to thank my co-authors from four continents who have graciously contributed their talent and time to assemble this first in a kind perspective on skin stress response pathways. Second,
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